Cincinnati is a typical American city where private automobiles are the primary means of transportation. It is not hard to envision the future of serious traffic tie-ups. Adequate mobility is a key factor for improving the residents’ life quality and consequently the prospects for economic development. The two options are 1) adding more highways and 2) improving mass transit. Within this contex...

The mapping of quantitative trait loci (QTL) is an important research question in animal and human studies. Missing data are common in such study settings, and ignoring such missing data may result in biased estimates of the genotypic effect and thus may eventually lead to errant results and incorrect inferences. In this article, we developed an expectation-maximization (EM)-likelihood-ratio te...

This paper mainly utilizes likelihood-based tests to detect rare variants associated with a continuous phenotype under the framework of kernel machine learning. Both the likelihood ratio test (LRT) and the restricted likelihood ratio test (ReLRT) are investigated. The relationship between the kernel machine learning and the mixed effects model is discussed. By using the eigenvalue representatio...

Sequencing studies have been discovering a numerous number of rare variants, allowing the identification of the effects of rare variants on disease susceptibility. As a method to increase the statistical power of studies on rare variants, several groupwise association tests that group rare variants in genes and detect associations between genes and diseases have been proposed. One major challen...

Detection of stationary targets in urban sensing and through-the-wall radar images using likelihood ratio test (LRT) detectors has recently been considered in the literature. A shortcoming of the LRT detectors is that appropriate probability density functions of target and clutter images need to be predefined. In most practical scenarios, this information is not available a priori, and the mism...

Following scant evidence for the effects of proximity to rail transit on auto use, we pinpoint the impacts of rail transit and neighborhood characteristics on both transit and car use in the Minneapolis-St. Paul metropolitan area. In this vein, we apply the structural equations modeling approach on 597 residents who moved into the Hiawatha light rail transit (LRT) corridor after it opened. Usin...

Genotype imputation has become standard practice in modern genetic studies. As sequencing-based reference panels continue to grow, increasingly more markers are being well or better imputed but at the same time, even more markers with relatively low minor allele frequency are being imputed with low imputation quality. Here, we propose new methods that incorporate imputation uncertainty for down...

BACKGROUND Rhinovirus infections cause exacerbations of asthma. We postulated that people with asthma are more susceptible to rhinovirus infection than people without the disease and compared the susceptibility of these groups. METHODS We recruited 76 cohabiting couples. One person in every couple had atopic asthma and one was healthy. Participants completed daily diary cards of upper-respira...

The clinical manifestations of lipodystrophy syndromes (LS) are hypoleptinemia, hyperglycemia, insulin resistance, dyslipidemia and hepatic steatosis. Leptin replacement therapy (LRT) is effective at improving these pathologies. Currently, there are no data compiling the evidence from the literature, and demonstrating the effect of LRT in LS patients. A systematic review of the MEDLINE and Coch...

Saat ini, Bus Rapid Transit (BRT) Bandar Lampung tidak memiliki informasi mengenai lokasi BRT. Ketiadaan BRT menyebabkan pengguna merasa kesulitan dan memilih angkutan umum lainnya. Dari hasil survey yang dilakukan, banyak membutuhkan untuk mengetahui estimasi waktu ke halte. Sehingga dibangun aplikasi menjawab kebutuhan pengguna. Penelitian ini dilakukan dengan menggunakan metode extreme progr...