Rheumatoid arthritis (RA) significantly affects quality of life. We recently cloned synoviolin, a RING-type E3 ubiquitin ligase implicated in the endoplasmic reticulum-associated degradation (ERAD) pathway. Synoviolin is highly expressed in rheumatoid synovial cells and may be involved in the pathogenesis of RA. Inhibition of synoviolin activity i...

presence of toxic metals in agricultural soils can impose adverse health impact on consumers. the main purpose of this study was to determine spatial distribution of elements fe, sb, mn in agriculture soils and crops of hamedan province in iran. soil samples (0-20 cm depth) were collected from an area of 2831 km2.  iron, antimony and manganese in samples of soil and agricultural crops were extr...

The objective of this study was to determine the distribution of selected metal concentrations (Cd, Pb, Cr and Fe) in the muscles of five fish species (Sander lucioperca, Liza auratus, Alosa caspia, Cyprinus carpio and Liza saliens) from Gorgan Bay the south-eastern Caspian Sea, in order to assess health risk to the human via fish consumption by graphite furnace atomic absorption spectrophotome...

Background & Aims of the Study: The current study was designed to determine the quality of sediments in Karun in Ahvaz, Iran, according to aquatic pollution indices. Materials and Methods: The sediment samples were obtained from six river stations in summer and winter. The sediment samples were air-dried, sifted, homogenized, and stored in plastic bags, and the concentrations of metals were...

The present study aimed at the formulation of matrix tablets for colon-specific drug delivery (CSDD) system of indomethacin (IDM) by applying liquisolid (LS) technique. A CSDD system based on time-dependent polymethacrylates and enzyme degradable polysaccharides was established. Eudragit RL 100 (E-RL 100) was employed as time-dependent polymer, whereas bacterial degradable polysaccharides were ...

Presence of toxic metals in agricultural soils can impose adverse health impact on consumers. The main purpose of this study was to determine spatial distribution of elements Fe, Sb, Mn in agriculture soils and crops of Hamedan Province in Iran. Soil samples (0-20 cm depth) were collected from an area of 2831 km2.  Iron, Antimony and Manganese in samples of soil and agricultural crop...

OBJECTIVE To identify the correlation between change in spinal deformities after surgical release and age at the time of surgery, and the effectiveness of surgical release in patients with neglected congenital muscular torticollis (CMT). METHODS This was a retrospective study of 46 subjects with neglected CMT who had undergone surgical release at age ≥5 years at a tertiary medical center betw...