In this article, our goal is twofold. First, we propose and compare two methods which process deformable registration to estimate patient specific lung and tumor displacements and deformation during free breathing from four-dimensional computed tomography (4D-CT) data. Second, we propose techniques to quantify the physiological parameters of motion nonlinearity and hysteresis. A Fréchet distanc...

The use of PET in the staging of patients with NSCLC is cost-effective, mainly due to a reduction in the number of futile operations. The addition of SUVmax to pathologic tumor size identifies a subgroup of patients at highest risk for death as a result of recurrent disease after resection. Tumor staging is more accurate with PET-CT than with CT alone or with PET alone. The greatest source of e...

Y-J. Chen, W-C. Chu, W-Y. I. Tseng Institute of Biomedical Engineering, National Yang-Ming University, Taipei, Taipei, Taiwan, Center for Optoelectronic Biomedicine, National Taiwan University College of Medicine, Taipei, Taipei, Taiwan Introduction Dynamic contrast-enhanced magnetic resonance image (DCE-MRI) has been known for its efficacy in characterization and treatment monitoring of tumors...

King’s College London, Division of Imaging Sciences and Biomedical Engineering, London, UK The impact of respiratory motion correction on quantitative accuracy in PET imaging is evaluated using real-time simulations for variable patient specific characteristics such as tumor malignancy and respiratory pattern. Respiratory patterns from real patients were acquired, with long quiescent motion per...

Proton radiation for cancer offers the ability to conform the high-dose region of radiation therapy to the tumor while reducing the dose of radiation to adjacent normal tissues. In lung cancer, this equates to greater sparing of uninvolved lung, heart, esophagus, and spinal cord. Sparing these normal tissues permits the delivery of higher-radiation doses to the tumor. Studies that compare the d...

introduction : pulmonary adenosquamous carcinoma is an uncommon histological variety of bronchogenic carcinoma, and has histologic areas differentiated as both squamous cell carcinoma and adenocarcinoma and has clinical behavior more like that of adenocarcinoma. tumor stage is higher at the time of diagnosis, and survival is poorer. case presentation : we present a 65 years old woman with bulgi...