Bacterial virulence is an integrative process that may involve quorum sensing. In this work, we compared by global expression profiling the wild-type entomopathogenic Photorhabdus luminescens subsp. laumondii TT01 to a luxS-deficient mutant unable to synthesize the type 2 quorum-sensing inducer AI-2. AI-2 was shown to regulate more than 300 targets involved in most compartments and metabolic pa...

Title of Document: S Y S T E M A T I C I N V E S T I G A T I O N O F QUORUM SENSING IN Escherichia coli JUN LI, Doctor of Philosophy, 2007 Directed By: Professor, William E Bentley, Chemical and Biomolecular Engineering High throughput techniques and advanced mathematical tools have enabled systematic investigations of biological systems with unparalleled precision. Not only molecular interacti...

Porphyromonas gingivalis is a major etiological agent in chronic and aggressive forms of periodontal disease. The organism is an asaccharolytic anaerobe and is a constituent of mixed species biofilms in a variety of microenvironments in the oral cavity. P. gingivalis expresses a range of virulence factors over which it exerts tight control. High-throughput sequencing technologies provide the op...

The emergence of multidrug resistance (MDR) and extensive drug (XDR) in Klebsiella pneumoniae strains has posed great threats to conventional antibiotics. Previous studies have shown that plant-derived flavonoids inhibitory functions against pathogens. However, K. pneumoniae, the antibacterial activity different growth biofilm formation remains a mystery. aim present study was evaluate antioxid...

Bacterial cell-to-cell communication (quorum sensing) refers to the regulation of bacterial gene expression in response to changes in microbial population density. Quorum sensing bacteria produce, release and respond to chemical signal molecules called autoinducers. Bacteria use two types of autoinducers, namely autoinducer-1 (AI-1) and autoinducer-2 (AI-2) where the former are N-acylhomoserine...

Bacterial cell-to-cell communication (‘quorum sensing’) is mediated by structurally diverse, small diffusible signal molecules which regulate gene expression as a function of cell population density. Many different Gramnegative animal, plant and fish pathogens employ Nacylhomoserine lactones (AHLs) as quorum sensing signal molecules which control diverse physiological processes including biolum...