Topical administration of non-steroidal anti-inflammatory drugs (NSAIDs) is generally considered safer than oral administration, although the former can occasionally induce cutaneous irritation. We hypothesized that the cutaneous irritation by topical NSAIDs might be suppressed by trehalose, which has protective effects on biological membranes. Using the three-dimensional cultured human skin mo...

Vinpocetine is a poorly water soluble drug, commonly used in treatment of various cerebral insufficiency conditions. The aim of this work was to formulate vinpocetine in the form of orally disintegrating tablets (ODTs) and enhance its solubility and dissolution rate. This objective was addressed using lyophilization technique of either solid dispersion using polyethylene glycol 4000 (PEG 4000) ...

Nanospheres and nanocapsules of an amphiphilic beta-cyclodextrin, beta-CDC6, were evaluated using a group of steroid drugs to determine the effect of drug physicochemical properties (e.g. partition coefficient, drug:CD association constant k1:1, aqueous solubility) on loading and release profiles of the nanoparticles. Model drugs used were hydrocortisone, testosterone and progesterone. Inclusio...

Low temperature vacuum drying is an alternative to sterile dry filling as a formulation approach for certain ethanol soluble substances that are poorly soluble or unstable in aqueous media. To date this ap­ proach has been limited to formulations containing the drug per se. However, several substances appear suitable as excipients in­ cluding urea, polyethylene glycol 4000, ascorbic acid, methy...

the aim of the present study was to prepare an oral tablet from liquid yogurt by reforming the physical properties for easy transportation, long-term storage and also as a complementary dairy product in case of nutrient deficiency. the liquid fresh yogurt was lyophilized at -40°c and 0.03 mtor pressure. the dry powder was homogenized by a 12 mesh size sieve. some tests such as carr’s compressib...

objective anti-rh d igg is used for the prevention of anti-d antibody production in rh- individuals who have been exposed to rh+ red blood cells. the stability of igg preparations as a solution is low, with a shelf life of a year or more. formulation of anti-rh d igg as a lyophilized preparation would decrease its degradation rate and increases its shelf life. the objective of this study was to...