to develop novel antimycobacterial agents, a new series of thiazolidinone-azole hybrids 4a-b, 5a-b and 6-13 were designed and synthesized. thiazolidin-4-ones (4a-b and 5a-b) were obtained by the reaction of schiff bases and hydrazones (2a-b and 3a-b) with mercaptoacetic acid. 5-benzylidene derivatives (6-13) were gained by treatment of 5a-b with appropriate benzaldehydes according to knoevenage...

interleukin-12 (il-12) is a key cytokine involved in regulating the balance between th1 and th2 cells by promoting th1 response. a reduced capacity to produce this cytokine could lead to aberrant th2 development. on the same aspect significant impact of il-12 on invariant natural killer t (inkt) cells was reported. therefore, we examined the serum levels of il-12 and the absolute number of peri...

bisphenol-a (bpa) is an industrial xenoestrogen used widely in our living environment. recently, several studies suggested that bpa has destructive effects on dna and chromosomes in normal body cells via estrogen receptors (er). therefore, bpa could be considered as an important mediator in many diseases such as cancer. however, there are still many controversial issues which need clarification...

objective: osteon has been introduced as a bone substitute material. it is biphasic calcium phosphate (bcp) that use in dentistry. the aim of the present study was to evaluate the effect of osteon on the proliferation, cell viability and differentiation of saos-2 cells in vitro. also it was compared with cerasorb bone graft. materials and methods: two different bone grafts materials, osteon an...

in rainfed areas of iran, cereal yields are low, variable and mainly as a result of inadequate and erratic seasonal rainfall and associated management factor, such as late sowing date (or late crop germination). in order to investigate the effects of single irrigation and nitrogen on bread wheat (triticum aestivum l. var. sabalan) a field experiment was conducted as split plot arranged in a ran...

the chemical composition of the essential oil of fruits of pimpinella haussknechtiiboiss.was studied by gc-ms. after gc-ms analysis, one unknown component (56.7%) was observed, which was not characterized in the gc-ms library. the essential oil of p.hauskenekhtii was injected to hplc using ymc-pak-sil column (250 × 20 mm) with gradient system of hexane (a), and hexane: ethyl acetate, 9:1 (b) to...

it is widely thought that bcl-2 family proteins regulate commitment to apoptosis primarily through their capacity to control the permeability of the mitochondrial outer membrane permeabilization (momp) triggers the release of multiple apoptogenic factors into the cytosol and, thereby apoptosis. various bcl-2 family members affect this key event of the apoptotic cascade in different ways, determ...

to report a case of buphthalmos with neurofibromatosis (nf-1) who suffered with blindness suffered enucleation. physical examination & histopathology were performed. physical examination revealed buphthalmos & vascularized cornea with lower lid ectropion and orbital deformity. histopathologic findings shows plexiform neurofibroma in orbital tissue with scleral wall involvement. and hamartomatou...

the multiple traveling salesman problem (mtsp) involves scheduling m > 1 salesmen to visit a set of n > m nodes so that each node is visited exactly once. the objective is to minimize the total distance traveled by all the salesmen. the mtsp is an example of combinatorial optimization problems, and has a multiplicity of applications, mostly in the areas of routing and scheduling. in this paper,...

introduction: in continuation of recent development of possible c-x-c chemokine receptor type 4 (cxcr4) imaging agents, we report the development of a possible cxcr4 targeted therapy agent. methods: [153sm]labeled 1,1′-[1,4-phenylenebis(methylene)] bis-1,4,8,11-tetraazacyclo -tetradecane ([153sm]-amd3100) was prepared using [153sm]smcl3 and amd-3100 for 24h at 50°c in acetate buffer.stability ...