Increasing evidences show that the actin cytoskeleton is a key parameter of the nuclear remodeling process in response to the modifications of cellular morphology. However, detailed information on the interaction between the actin cytoskeleton and the nuclear lamina was still lacking. We addressed this question by constraining endothelial cells on rectangular fibronectin-coated micropatterns an...

Increased mobility of chromatin surrounding double-strand breaks (DSBs) has been noted in yeast and mammalian cells but the underlying mechanism and its contribution to DSB repair remain unclear. Here, we use a telomere-based system to track DNA damage foci with high resolution in living cells. We find that the greater mobility of damaged chromatin requires 53BP1, SUN1/2 in the linker of the nu...

Cyanobacteria are able to tolerate, and even metabolize, moderate doses of organochlorine pesticides, such as lindane (γ-hexachlorocyclohexane), one the most persistent widely used in recent decades. Previous work showed that Microcystis aeruginosa PCC 7806 degrades that, presence pesticide, microcystin synthesis is enhanced. In this work, using silico approaches, we have identified M. putative...

INTRODUCTION The interprofessional education (IPE) community has long recognized that scholarly output related to program/study design, outcomes, and evaluation is needed strengthen the IPE evidence base. We developed, implemented, evaluated a university-wide writers’ workshop address this need.METHODS Awardees of Linking Interprofessional Networks for Collaboration (LINC) Seed Grant Program, w...

inhibitor of the lipid peroxidation induced by iron salts and ascorbic acid.7) It has been revealed that mammalian cells in culture do not always Tequire transferrin, ifiTon is provided as a complex with appropriate chelators.8) To design a protein-free medium for hybridomas, we studied the effect of ferric citratc as an alternative to transferrin on thc proliferation of hybridomas. Mouse hybri...