Advances of nanotechnology have led to the development of nanomaterials with both potential diagnostic and therapeutic applications. Among them, superparamagnetic iron oxide (SPIO) nanoparticles have received particular attention. Over the past decade, various SPIOs with unique physicochemical and biological properties have been designed by modifying the particle structure, size and coating. Th...

Magnetically labelled cells are used for in vivo cell tracking by MRI, used for the clinical translation of cell-base therapies. Studies involving magnetic labelled cells may include separation of labelled cells, targeted delivery and controlled release of drugs, contrast enhanced MRI and magnetic hyperthermia for the in situ ablation of tumours. Dextran-coated super-paramagnetic iron oxide (SP...

Magnetic hyperthermia is a new type of cancer treatment designed for overcoming resistance to chemotherapy during the treatment of solid, inaccessible human tumors. The main challenge of this technology is increasing the local tumoral temperature with minimal side effects on the surrounding healthy tissue. This work consists of an in vitro study that compared the effect of hyperthermia in respo...

Hyperthermia is an experimental/adjuvant therapeutic modality for cancer. Combining hyperthermia with the non-invasive metabolic studies using magnetic resonance (MR) is an interesting area of research and can provide useful information. In this paper, feasibility of using the same radio frequency source for carrying out combined hyperthermia and MR studies is demonstrated. A conventional RF hy...

Heat therapies such as hyperthermia and thermoablation are very promising approaches in the treatment of cancer. Compared with available hyperthermia modalities, magnetic fluid hyperthermia (MFH) yields better results in uniform heating of the deeply situated tumors. In this approach, fluid consisting of superparamagnetic particles (magnetic fluid) is delivered to the tumor. An alternating (ac)...

Recent advances in nanomaterials science contributed to develop new micro- and nano-devices as potential diagnostic and therapeutic tools in the field of oncology. The synthesis of superparamagnetic nanoparticles (SPMNPs) has been intensively studied, and the use of these particles in magnetic hyperthermia therapy has demonstrated successes in treatment of cancer. However, some physical limitat...

Implantable long-acting delivery systems able to minimize off-target side effects and locally provide non-invasive imaging reporting are of utmost importance offer a precise treatment internal diseases accurate assessment disease progression, such as in local infections tumor relapse following surgery, among other diseases. Here, biocompatible xanthan gum/Fe3O4-based drug-loaded magnetic nanopa...

Abstract Two-dimensional transition metal carbides and nitrides (MXenes) nanosheets with high photothermal conversion efficiency as well stability can efficiently generate remarkable hyperthermia for therapy (PTT) of cancer. However, mono-MXenes cannot exhibit precise diagnosis treatment to complete ablation cancer cells in the PTT process. To overcome this dilemma, an “all-in-one” nanoplatform...

background: the purpose of this study was to evaluate the dependency of magica polymer gel dosimeter response (r2) on different electron energies as well as on different mean dose rate for a standard clinically used linear accelerator. materials and methods: the sensitivity of the dosimeter was represented by the slope of calibration curve in the linear region measured for each modality. a cali...