BACKGROUND Malaria remains a problem for many countries classified as malaria free through cases imported from endemic regions. Imported cases to non-endemic countries often result in delays in diagnosis, are expensive to treat, and can sometimes cause secondary local transmission. The movement of malaria in endemic countries has also contributed to the spread of drug resistance and threatens l...

This article explores the question of how malaria “ends” in Myanmar, since has been categorized both as an epidemic and being endemic on seemingly countless occasions. The example reveals some limitations understanding a disease within single category experience, such “epidemic.” In case malaria, is shifting term that best understood point at which health authorities decide to intervene disease...

Over the past decade, global malaria-related mortality has declined dramatically because of combined international actions that have defined and prioritized national and regional efforts to reduce the incidence of malaria, with the ultimate goal of eradication. Vector control strategies using insecticide-treated nets (ITNs) and indoor residual spraying (IRS) in African countries have contribute...

A concerted effort to control malaria in Africa has produced dramatic reductions in childhood death in the past decade. This early success has prompted the global community to commit to eradication of malaria deaths and eventually all transmission. Evidence suggests that this is a feasible goal using currently available interventions, augmented with newer tools such as vaccines, which are in de...

Prospects for malaria eradication will be greatly enhanced by an effective vaccine, but parasite genetic diversity poses a major impediment to malaria vaccine efficacy. In recent pre-clinical and field trials, vaccines based on polymorphic Plasmodium falciparum antigens have shown efficacy only against homologous strains, raising the specter of allele-specific immunity such as that which plague...