نتایج جستجو برای: malonyl coa decarboxylase

تعداد نتایج: 36212  

Journal: :The Biochemical journal 2005
Takhar Kasumov Jillian E Adams Fang Bian France David Katherine R Thomas Kathryn A Jobbins Paul E Minkler Charles L Hoppel Henri Brunengraber

We reported previously that a substantial fraction of the acetyl groups used to synthesize malonyl-CoA in rat heart is derived from peroxisomal beta-oxidation of long-chain and very-long-chain fatty acids. This conclusion was based on the interpretation of the 13C-labelling ratio (malonyl-CoA)/(acetyl moiety of citrate) measured in the presence of substrates that label acetyl-CoA in mitochondri...

Journal: :The Biochemical journal 1990
M S Murthy S V Pande

By using octyl glucoside in the presence of glycerol, it is possible to obtain a solubilized malonyl-CoA-sensitive carnitine palmitoyltransferase (CPTo) from the outer membranes of rat liver mitochondria. H.p.l.c. on hydroxyapatite column has now allowed a clear separation of the CPTo from the malonyl-CoA-insensitive CPT activity of the inner membranes (CPTi). The separated CPTo activity showed...

Journal: :PLOS Computational Biology 2021

Acrylic acid is a value-added chemical used in industry to produce diapers, coatings, paints, and adhesives, among many others. Due its economic importance, there currently need for new sustainable ways synthesise it. Recently, the focus has been laid use of Escherichia coli express full bio-based pathway using 3-hydroxypropionate as an intermediary through three distinct pathways (glycerol, ma...

Journal: :American journal of physiology. Endocrinology and metabolism 1999
Asish K Saha D Ross Laybutt David Dean Demetrios Vavvas Elena Sebokova Bronwyn Ellis Iwar Klimes Edward W Kraegen Eleazar Shafrir Neil B Ruderman

In liver, insulin and glucose acutely increase the concentration of malonyl-CoA by dephosphorylating and activating acetyl-CoA carboxylase (ACC). In contrast, in incubated rat skeletal muscle, they appear to act by increasing the cytosolic concentration of citrate, an allosteric activator of ACC, as reflected by increases in the whole cell concentrations of citrate and malate [Saha, A. K., D. V...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2003
Zhiyuan Hu Seung Hun Cha Shigeru Chohnan M Daniel Lane

Previous studies showed that i.p. administration of C75, a potent inhibitor of fatty acid synthase (FAS), blocked fasting-induced up-regulation of orexigenic neuropeptides and down-regulation of anorexigenic neuropeptides in the hypothalami of mice. As a result, food intake and body weight were drastically reduced. Here we provide evidence supporting the hypothesis that hypothalamic malonyl-CoA...

Journal: :Cardiovascular research 1996
J L Hall G D Lopaschuk A Barr J Bringas R D Pizzurro W C Stanley

OBJECTIVE Malonyl CoA is an important regulator of fatty acid oxidation in the heart secondary to its ability to inhibit carnitine palmitoyltransferase 1 (CPT 1). Malonyl CoA is produced from acetyl CoA in a reaction catalyzed by acetyl CoA carboxylase (ACC). In this study we determined if alterations in malonyl CoA regulation of fatty acid metabolism are involved in the increase in energy tran...

Journal: :Applied and environmental microbiology 2014
Junjun Wu Oliver Yu Guocheng Du Jingwen Zhou Jian Chen

Malonyl coenzyme A (malonyl-CoA) is an important precursor for the synthesis of natural products, such as polyketides and flavonoids. The majority of this cofactor often is consumed for producing fatty acids and phospholipids, leaving only a small amount of cellular malonyl-CoA available for producing the target compound. The tuning of malonyl-CoA into heterologous pathways yields significant p...

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