BACKGROUND Use of nonsteroidal anti-inflammatory drugs (NSAID) has been associated with a decrease in breast cancer risk, but it is unknown if they also reduce mammographic density, a strong intermediate marker of breast cancer risk. METHODS We investigated NSAID use and mammographic density in 29,284 postmenopausal women who had two screening mammograms at Group Health in Seattle. We used ph...

Average Glandular Dose (AGD) is the quantity generally accepted for dose monitoring of X ray mammographic examinations. A survey of breast characteristics (compressed breast thickness, peak breast density) and AGD values was carried out on a database describing the acquisition conditions of 147,487 routine mammographic images acquired in Europe, North America and Asia-Pacific on GE Healthcare S...

Mammographic density is associated with risk of breast cancer, and factors that change density may also change risk. There has, however, been little research into how change in serial mammograms is best detected. The purpose of the work described here was to examine the effects of different reading conditions on the detection of change in mammographic features. Mammograms were selected from wom...

Members of the insulin-like growth factor family have been associated with breast cancer risk and mammographic breast density, one of the strongest known breast cancer risk indicators. The aim of this cross-sectional study was to examine the association of levels of C-peptide (a marker of insulin secretion) with mammographic breast density among 1,499 healthy women recruited during screening ma...

Breast cancer is the most common cancer in women and the number of incidences keeps rising. Mammographic breast density has been recognized as a very important breast cancer risk and can also mask abnormalities. Information regarding mammographic breast density may be used for planning individualized breast cancer screening and treatment. Thus, breast density is increasingly assessed as the lim...

Early-life exposures may influence the development of breast cancer. The authors examined the association of childhood and adolescent anthropometric factors, physical activity levels, and diet with adult mammographic breast density, a strong risk factor for breast cancer. Women in the Minnesota Breast Cancer Family Study cohort who had undergone mammograms but had not had breast cancer (n=1,893...