Local drug delivery has received much recognition in recent years, yet it is still unpredictable how drug efficacy depends on physicochemical properties and delivery kinetics. The purpose of the current study is to provide a useful mathematical model for drug release from a drug delivery device and consecutive drug transport in biological tissue, thereby aiding the development of new therapeuti...

Experimental data on the kinetics of propane hydrate dissociation at 0.1 MPa and different external temperatures were obtained. A two-stage mechanism of hydrate dissociation was observed visually. In the first stage hydrate dissociated into metastable water and gas. During the second stage the metastable water crystallized into ice. The release of metastable water during hydrate dissociation an...

Derived by means of EBSD, statistics crystal curvature in quenched low carbon steel is analyzed with allowance for its transformation kinetics terms dilatometry data. Based on spectra sensitive to the distribution dislocation density, fractions martensite and bainite are quantified at high cooling rates. Distinction between resulting microstructures ascribed various proportions their athermal t...

Utilizing electrical resistance measurements in combination with strain observations on single crystals, it was possible to distinguish the austenite to martensite transformation from the detwinning of the martensite behavior during deformation of NiTiCu shape memory alloys. It was found that the electrical resistance change associated with the detwinning of the martensite variants was as high ...

Stress-induced martensitic transformations are clarified in classes of NiMnGa alloys which undergo the stress-free, thermal-induced inter-martensite transformation austenite (A) pre-martensite (PM) martensite. This study implements a comprehensive experimental approach, including analysis of the strain–temperature and stress–strain response, which discloses stress-induced inter-martensite trans...

dual phase steels with different martensite volume fraction and morphology were tensile tested at a temperature range of 25 to 5500c. stress-strain curves of all steels showed serration flow at temperatures of 250 and 3500c, and smooth flow at the other temperatures. both yield and ultimate tensile strengths increased with increasing testing temperature up to about 4500c and then decreased at h...

A physically-based two-site mean field model has been developed to describe the microstructural evolution due to recrystallization during and after deformation. The model has been applied to predict the recrystallized fraction, recrystallized grain size, and flow stress of 304L austenitic stainless steel during discontinuous dynamic recrystallization (DDRX), post-dynamic recrystallization (PDRX...

A kinetic model for the diffusion-controlled annealing of excess vacancies under the experimentally relevant, non-isothermal condition of time-linear heating is presented and applied to dilatometry. The evolution of the vacancy concentration with time is quantitatively analyzed, considering as ideal sinks either dislocations or grain boundaries of spherical- or cylindrical-shaped crystallites. ...

A phenomenological macroscopic plasticity model is developed for steels that exhibit strain-induced austenite-to-martensite transformation. The model makes use of a stress-state dependent transformation kinetics law that accounts for both the effects of the stress triaxiality and the Lode angle on the rate of transformation. The macroscopic strain hardening is due to nonlinear kinematic hardeni...