Vincristine is a microtubule-destabilizing antimitotic drug that has been used in cancer therapy for over 40 years. However, the knowledge on vincristine-induced cell death pathways is still sparse. Here, we show that vincristine induces dramatic changes in the lysosomal compartment and sensitizes cells to lysosomal membrane permeabilization. In HeLa cervix carcinoma cells, vincristine induced ...

background avoidable mortality as an indicator for assessing the health system performance has caught the attention of researchers for a long time. in this study we aimed to compare the health system performance using this indicator in rural and urban areas of one of iran’s southern provinces.   methods all deaths (29916) which happened during 2004–2011 in bushehr province were assessed. nolte ...

Innovative host-directed drug therapies are urgently required to treat sepsis. We tested the effect of a small-volume 0.9% NaCl adenosine, lidocaine, and Mg2+ (ALM) bolus and a 4-h intravenous infusion on survivability in the rat model of polymicrobial sepsis over 6 days. ALM treatment led to a significant increase in survivability (88%) compared to that of controls (25%). Four controls died on...

background: massive ischemic stroke causes significant mortality and morbidity in stroke patients. the main treatments for massive ischemic stroke are recombinant tissue plasminogen activator (rtpa), craniotomy, and endovascular interventions. due to destructive  effects  of   bradykinin  on  the  nervous system in ischemic stroke, it seems reasonable that using noscapine as a bradykinin antago...

the article reports a clinical case of a 39-year-old male patient who was admitted in the emergency room in shock. the clinical exams and additional tests identified a right massive hemothorax, without apparent etiological factors. he was submitted to an emergency right thoracotomy. a bulky varicose formation in the diaphragmatic surface, with evident laceration and haemorrhage was identified. ...

the trace element contents on the surface originated from mineralization would depend to the thickness of the calcrete layer above the ore deposit on the surface. a very thick layer of calcrete may not allow for much dispersion of the elements of interest in the surface. these elements may be concentrated in non-magnetic and magnetic part of calcrete. based on the current research, mineralogica...