Probiotics have great potential in regulating intestinal pain. In this study, the effects of Lactobacillus plantarum AR495 on visceral sensitivity and gut microbiota irritable bowel syndrome (IBS) rats were studied. The results showed that tryptase released after mast cell activation degranulation plays a key role pain, L. reduced stimulation colonic cells expression protease-activate...

BACKGROUND Stress is a known cause of hair loss in many species. OBJECTIVE In this study, we investigated the role of acute stress on hair growth using a rat model. METHODS Rats were immobilized for 24 hours and blood samples, and skin biopsies were taken. The effect of stress-serum on the in vitro proliferation of rat and human dermal papilla cells (hDPCs), as well as serum cortisol and co...

Tryptase, a neutral protease of human mast cells, is a potentially important indicator of mast cell involvement in various clinical conditions. The current study examined the time course of appearance and disappearance of tryptase in the circulation after an anaphylactic event and the stability of both endogenous and exogenous tryptase in terms of freeze-thawing and temperature. The peak level ...

Increased blood-brain-barrier (BBB) permeability precedes any clinical or pathologic signs and is critical in the pathogenesis of multiple sclerosis (MS) and brain metastases. CD4+ TH1 cells mediate demyelination in MS, but how they get sensitized and enter the brain to induce brain inflammation remains obscure. TH2 cytokines associated with allergic disorders have recently been implicated in M...

Systemic mastocytosis (SM) is a condition associated with clonal neoplastic proliferation of mast cells. In up to 40% of systemic mastocytosis cases, an associated clonal hematological disease of non-mast cell lineage, such as acute myeloid leukemia (AML), is diagnosed before, simultaneously with, or after the diagnosis of SM. Herein, we report a case of a 30-year-old man diagnosed with AML wit...

A number of available studies have focused on the role of mastocytes and their angiogenic factors, such as tryptase expression, in cancer growth as a major research objective. Cardiac myxoma is a rare neoplasia and is the most common primary tumor of the heart. The cellular elements of cardiac myxoma have an endothelial phenotype; however, its histogenesis remains unclear. Currently, no availab...

The aim of this study was to quantify the distribution microvessels and mast cells in all three parts trigeminal ganglion (TG). Statistical analyses were applied investigate possible micromorphological regional differences their density. Five serially sectioned human TGs prepared for CD34 cell tryptase immunostaining. following quantifications performed microscopic fields TG: microvessel densit...

Increased mast cell numbers and mast cell activation represent one of the prevalent etiologic theories for interstitial cystitis, an inflammatory condition in the bladder. This study was designed primarily to determine whether increased mast cell tryptase in the bladder wall may play a role in activating bladder endothelial cell phospholipase A(2) (PLA(2)), leading to increased inflammatory pho...