Maternal mortality ratio in Nigeria is one of the highest in the world. This paper reports a facility based study in north-central Nigeria to determine the magnitude, trends, causes and characteristics of maternal deaths before and after the launch of the Safe Motherhood Initiative in Nigeria, with a view to suggesting strategic interventions to reduce these deaths. The records of all deliverie...

Background & Aims: Detection of maternal risk factors associated with neonatal mortality helps to identify high-risk infants and prevent neonatal death. It can also contribute to the design more effective prenatal care. This study was performed aiming to evaluate the maternal risk factors associated with mortality in preterm infants in Mashhad Ghaem Hospital, Iran, during 2009-2014. Methods: Th...

Acute lymphoblastic leukemia (ALL) is one of the most prevalent hematologic malignancies in children. Although the cure rate of ALL has improved over the past decades, the most important reason for ALL treatment failure is multidrug resistance (MDR) phenomenon. The current study aims to explain the mechanisms involved in multidrug resistance of childhood ALL, and introduces ATP-binding cassette...

Chemoresistance is one of the main obstacles to successful cancer therapy and is frequently associated with multidrug resistance (MDR). One of the most studied mechanisms of MDR is the high expression of ATP-binding cassette (ABC) transporters. Here, we demonstrated that NP-1250, an ABCG2 inhibitor, induced apoptotic cell death in ABCG2-overexpres...

944 Emerging Infectious Diseases • www.cdc.gov/eid • Vol. 13, No. 6, June 2007 Septic shock developed in 4 (14.8%) of the 27 neutropenic patients with A. baumannii–associated bacteremia, and 2 (7.4%) of the 27 died (Table). However, we did not fi nd a statistically signifi cant association between death among patients with bacteremia caused by MDR A. baumanni (1 death) compared with death among...

High Maternal mortality continues to be a challenge in reaching MDG 5 target. India still has not shown satisfactory progress in its MDG 5 achievements. Maternal death audit is a way to understand the hurdles and bottlenecks in reaching the target. The main objective is 1.To analyze the number and causes of maternal deaths at Pravara Rural hospital during study period 2.To find out the avoidabl...

Background: Identifying determinants of maternal mortality is essential in developing appropriate health policies for reduction of maternal death. This study aimed to determine the determinants of maternal mortality in Iran during 1990- 2015 and also to identify the trends of these determinants during the same period. Methods: This is a quantitative longitudinal study that has been conducted a...

The focus of this mini-review is to identify non-toxic compounds isolated from natural sources (plants) that exhibit specific activity against efflux pumps of specific multidrug-resistant (MDR) cancer cell lines, inhibit proliferation of the MDR cancer cell lines and inhibit the activity of overexpressed efflux pumps of the MDR cancer cell line.