Thyroglobulin (TG) is a homodimeric glycoprotein synthesized by the thyroid gland. To date, two hundred twenty-seven variations of TG gene have been identified in humans. Thyroid dyshormonogenesis due to mutations an estimated incidence approximately 1 100,000 newborns. The clinical spectrum ranges from euthyroid mild or severe hypothyroidism. purpose present study was identify and characterize...

Thyroid dysfunction is the commonest endocrine disorder in pregnancy apart from diabetes. Thyroid hormones are essential for fetal brain development in the embryonic phase. Maternal thyroid dysfunction during pregnancy may have significant adverse maternal and fetal outcomes such as preterm delivery, preeclampsia, miscarriage and low birth weight. In this review we discuss the effect of thyroid...

Maternal thyroid disease can affect the newborn baby leading to neonatal hyperthyroidism or hypothyroidism. Babies born to mothers with thyroid disease get thyroid function tests (TFT) done randomly irrespective of the nature of maternal thyroid disease and medication .The aim of this study was to determine which babies are at-risk and need thyroid function monitoring besides a simple Newborn s...

Not unlike screening for gestational diabetes, controversy prevails over the value of screening for thyroid disease in pregnancy. Fortunately, overt hypothyroidism is rare in pregnancy (0.3-0.5%) because it is associated with infertility and increased rates of first trimester miscarriage. Studies suggest that obstetric complications such as hypertension, placental abruption, preterm delivery, p...

BACKGROUND Over the last decade there has been enhanced awareness of the appreciable morbidity of thyroid dysfunction, particularly thyroid deficiency. Since treating clinical and subclinical hypothyroidism may reduce adverse obstetric outcomes, it is crucial to identify which interventions are safe and effective. OBJECTIVES To identify interventions used in the management of hypothyroidism a...

Background: Congenital hypothyroidism (CH) can influence neonates’ neurodevelopment. There are controversies on the cause of infantile and its relationship with maternal hypothyroidism. Objectives: This study aimed to investigate between incidence CH. Methods: cross-sectional was conducted 712 newborns born in Fars province, Iran, 2018 2020, identified through national screening program for gen...