Integrins are heterodimeric (alpha, beta) cell adhesion receptors. We demonstrate that point mutations in the cytoplasmic domains of both the alpha and beta subunits promote constitutive signaling by the integrin alphaIIbbeta3. By generating charge reversal mutations, we show these "activating" mutations may act by disrupting a potential salt bridge between the membrane-proximal portions of the...

An R-module M is observable ii all its elements can be distinguished by observing them by means of linear morphisms from M to R. We show that free observable R-modules can be explicitly described as the cores of the nal power domains with characteristic semiring R. Then, the general theory is applied to the cases of the lower and the upper semiring. All lower modules are observable, whereas the...

Collagen VI is a ubiquitous extracellular matrix protein that assembles into beaded microfibrils that form networks linking cells to the matrix. Collagen VI microfibrils are typically formed from a heterotrimer of the α1, α2, and α3 chains. The α3 chain is distinct as it contains an extended N terminus with up to 10 consecutive von Willebrand factor type A-domains (VWA). Here, we use solution s...

Protein kinase B (PKB) is a proto-oncogene that is activated in signaling pathways initiated by phosphoinositide 3-kinase. Chromatographic separation of brain cytosol revealed a kinase activity that phosphorylated and activated PKB only in the presence of phosphatidylinositol-3,4,5-trisphosphate [PtdIns(3,4,5)P3]. Phosphorylation occurred exclusively on threonine-308, a residue implicated in ac...

The variety of power domain constructions proposed in the literature is put into a general algebraic framework. Power constructions are considered algebras on a higher level: for every ground domain, there is a power domain whose algebraic structure is speciied by means of axioms concerning the algebraic properties of the basic operations empty set, union, singleton, and extension of functions....

In this paper, we describe three distinct monoids over domains, each with a commutative analog, the latter of which define bag domain monoids. Our results were inspired by work by Varacca (Varacca 2003), and they lead to a constructive approach to his Hoare indexed valuations over a continuous poset P . We use our constructive approach to describe an analog of the probabilistic power domain and...

This paper studies the possibilities of the Linear Matrix Inequality (LMI) characterization of the matrix cones formed by nonnegative complex Hermitian quadratic functions over specific domains in the complex space. In its real case analog, such studies were conducted in Sturm and Zhang [11]. In this paper it is shown that stronger results can be obtained for the complex Hermitian case. In part...

Peroxidasins represent the subfamily 2 of the peroxidase-cyclooxygenase superfamily and are closely related to chordata peroxidases (subfamily 1) and peroxinectins (subfamily 3). They are multidomain proteins containing a heme peroxidase domain with high homology to human lactoperoxidase that mediates one- and two-electron oxidation reactions. Additional domains of the secreted and glycosylated...

This paper proposes and studies the performance of a preconditioner suitable for solving a class of symmetric positive de nite systems, Âx = b, which we call p-level lower rank extracted systems (p-level LRES), by the preconditioned conjugate gradient method. The study of these systems is motivated by the numerical approximation of integral equations with convolution kernels de ned on arbitrary...