Cocaine cardiotoxicity is partly due to sympathetic activation of the heart resulting from inhibition of catecholamine uptake at the sympathetic nerve terminal and possible central sympathetic stimulation and/or inhibition. This study evaluated the role of postsynaptic mechanisms in potentiation by cocaine of cardiac adrenergic responses. Cardiovascular responses (arterial and left ventricular ...

the purpose of this study was to investigate the effect of aerobic exercise with intensity (60-65%, maximal heart rate) with consumption vitamin e on glutathion peroxidase activity and oxidative stress indicators and muscle damage of active men student. for this reason 45 male active students were purposefully selected and randomly divided in to three groups. the participants trained according ...

given a non-abelian finite group $g$, let $pi(g)$ denote the set of prime divisors of the order of $g$ and denote by $z(g)$ the center of $g$. thetextit{ prime graph} of $g$ is the graph with vertex set $pi(g)$ where two distinct primes $p$ and $q$ are joined by an edge if and only if $g$ contains an element of order $pq$ and the textit{non-commuting graph} of $g$ is the graph with the vertex s...

L-serine is a precursor of central neurotransmitters. Its cardiovascular effects are largely unstudied. We compared the in vitro effects of L-serine and acetylcholine in phenylephrine-constricted third-order branches of mesenteric arterioles in the NO synthase inhibitor N(G)-nitro L-arginine methyl ester (L-NAME), pretreated hypertensive rats, and a control group of normotensive male Sprague-Da...

The biochemical mechanism responsible for the osmotic sensitivity of glutamate oxidation in oyster (Crassostrea virginica Gmelin) gill mitochondria was examined. The relative roles of osmotically induced changes in matrix divalent cation concentration and ionic strength were determined. The calcium-magnesium ionophore A23187 inhibited glutamate oxidation in both low(40% of control rate) and hig...

OBJECTIVE Ketosis-prone atypical diabetes (KPD) is a subtype of diabetes in which the pathophysiology is yet to be unraveled. The aim of this study was to characterize β- and α-cell functions in Africans with KPD during remission. RESEARCH DESIGN AND METHODS We characterized β- and α-cell functions in Africans with KPD during remission. The cohort comprised 15 sub-Saharan Africans who had bee...