The selection of human cancer cell lines in cis-diamminedichloroplatinum(II) (CDDP, best known as cisplatin) is accompanied by stereotyped alterations that contribute to the acquisition of a CDDP-resistant state. Thus, CDDP resistance often leads to the upregulation of the DNA repair enzyme poly (ADP-ribose) polymerase-1 (PARP1) with the consequent intracellular accumulation of poly (ADP-ribose...

Problem Statement: In general, the drinking water systems sourced from ground water (GW) contains chemicals at double the current maximum contaminant levels (MCL) of colloids. However, due to increasing demand of water, groundwater may be subjected to over-exploitation and the natural equilibrium is thus disturbed. A steady-state condition is established between seawater and freshwater in a coa...

Arsenic released by bottom sediments was determined by experiments in which the sediments were artificially re-suspended using a particle entrainment simulator (PES) to simulate river conditions. Sediment cores were collected from various tributaries to drinking water reservoirs in Connecticut spiked with arsenic, and run in the PES at simulated bed-flow shear stresses from 0.0 to 0.6 N/m(2). U...

Medial collateral ligament (MCL) can be frequently damaged with ACL injuries, especially during external rotation, slight flexion and valgus loading of the knee. Inpatients combined ACL (partially ruptured) and MCL injuries, percutaneous MCL reefing by using PDS suture material, shrinkage with radiofrequency and regularization of the ACL was performed. The aim of this study was to describe the ...

Water samples from 78 private potable wells in southern NJ were collected for mercury analysis in 19911992. The wells are located in Atlantic, Burlington, Camden, Cape Map and Ocean Counties. Total mercury concentrations varied from 1 ng/L to over 36 Fg/L. The dominant form in which mercury occurred in the wells sampled was inorganic, although monomethylmercury was present in some wells compris...

BACKGROUND Concerns for arsenic exposure are not limited to toxic waste sites and massive poisoning events. Chronic exposure continues to be a major public health problem worldwide, affecting hundreds of millions of persons. OBJECTIVES We reviewed recent information on worldwide concerns for arsenic exposures and public health to heighten awareness of the current scope of arsenic exposure and...

A study was conducted on physico-chemical parameters and heavy metal contents of water from the mangrove swamps of Lagos lagoon, Nigeria. The study was aimed at assessing its suitability for fish production and as well as its safety for drinking purpose in man. In all eleven (11) physical and chemical parameters and six (6) heavy metals were investigated for water quality assessment of the lago...

Breast cancer cells generally develop resistance to TNF-Related Apoptosis-Inducing Ligand (TRAIL) and, therefore, assistance from sensitizers is required. In our study, we have demonstrated that Spleen tyrosine kinase (Syk) inhibitor Bay 61-3606 was identified as a TRAIL sensitizer. Amplification of TRAIL-induced apoptosis by Bay 61-3606 was accompanied by the strong activation of Bak, caspases...

The purpose of the present study was to comprehensively evaluate available golf course water quality data and assess the extent of impacts, as determined by comparisons with toxicologic and ecologic reference points. Most water quality monitoring studies for pesticides have focused on agriculture and often the legacy chemicals. There has been increased focus on turf pesticides since the early 1...

Microplastics (MPs) are prevalent in marine ecosystems. Because toxicants (termed here "co-contaminants") can sorb to MPs, there is potential for MPs to alter co-contaminant bioavailability. Our objective was to demonstrate sorption of two co-contaminants with different physicochemistries [phenanthrene (Phe), log10Kow=4.57; and 17α-ethinylestradiol (EE2), log10Kow=3.67] to MPs; and assess wheth...