OBJECTIVE To test the hypothesis that women with subclinical hypothyroidism (SH) have forearm vascular conductance (FVC) impaired during mental stress. SUBJECTS AND METHODS We evaluated 20 women with SH and 21 euthyroid (Control group), matched for age (p = 0.699) and body mass index (p = 0.462). Muscle blood flow (MBF) was assessed by venous occlusion plethysmography and blood pressure by Di...

We compared the effects of hypertonic saline 7.2%/6% hydroxyethyl starch (HSS-HES) and isotonic saline 0.9%/6% hydroxyethyl starch (ISS-HES) on ileal microcirculatory blood flow (MBF) at the initial phase of septic shock. Pigs were anesthetized and mechanically ventilated. Catheters were inserted into right atrium, pulmonary artery, carotid artery, and portal vein for hemodynamic measurements a...

Myocardial blood flow (MBF) can be estimated from dynamic contrast enhanced (DCE) cardiac CT acquisitions, leading to quantitative assessment of regional perfusion. The need for low radiation dose and the lack of consensus on MBF estimation methods motivates this study to refine the selection of acquisition protocols and models for CT-derived MBF. DCE cardiac CT acquisitions were simulated for ...

AIMS Absolute quantification of myocardial blood flow (MBF) with (15)O-water cardiac positron emission tomography (PET)/CT has recently demonstrated to hold promising diagnostic value for the detection of coronary artery disease (CAD). However, methodological differences in utilized analysis software packages (SP) could affect generated MBF values, potentially prohibiting widespread clinical ap...

Chronic Myocardial Hiberation The study of Vanoverschelde et al' demonstrated significant abnormalities on morphological analysis of myocardial biopsies from patients with chronic myocardial hibernation. These morphological changes are very similar to those described previously2 and do not occur in stunning; thus, the investigators correctly state that their patients with left ventricular dysfu...

BACKGROUND Paraoxonase 1 [PON1] is recognized as a protective enzyme against LDL oxidation, and PON1 polymorphism has been described as a factor influencing coronary heart disease [CHD] free survival. As coronary vasoreactivity is a surrogate of future cardiovascular events, we aimed at assessing the respective effect of the PON1 genotype and activity on coronary vasoreactivity in a population ...

Background Quantitative myocardial perfusion imaging requires correct measurement of arterial Gd concentration as the input function (AIF). An underestimation of AIF Gd concentration will lead to overestimation of myocardial blood flow (MBF). One source of this underestimation is the T2* effect due to high Gd concentration in the AIF measurement. Despite the short echo time (0.65 ms) used in th...

BACKGROUND Although impairment in perfusion reserve is well recognized in hibernating myocardium, there is substantial controversy as to whether resting myocardial blood flow (MBF) is reduced in such circumstances. Quantitative first-pass cardiovascular magnetic resonance (CMR) perfusion imaging allows absolute quantification of MBF. We hypothesized that MBF assessed at rest by quantitative CMR...

Chronic Myocardial Hiberation The study of Vanoverschelde et al' demonstrated significant abnormalities on morphological analysis of myocardial biopsies from patients with chronic myocardial hibernation. These morphological changes are very similar to those described previously2 and do not occur in stunning; thus, the investigators correctly state that their patients with left ventricular dysfu...

Background Following acute myocardial infarction (AMI), microvascular integrity and function may be compromised as a result of microvascular obstruction (MVO) and vasodilator dysfunction [1,2]. It has been observed that both infarct and remote myocardial territories may exhibit impaired myocardial blood flow (MBF) patterns associated with abnormal vasodilator response [3]. Arterial spin labeled...