CONTEXT The available data concerning oxidant stress and antioxidant capacity in hypothyroidism are scanty and inconclusive. While some authors suggest that tissues may be protected from oxidant damage because of a hypometabolic state in hypothyroidism, others report increased oxidative stress in hypothyroidism. Selenium acts as a cofactor for the thyroid hormone (TH) deiodinases that activate ...

Numerous experimental and clinical analyses of biomechanical injury have served to elucidate the pathophysiologic events involved in Traumatic Brain Injury(TBI).Secondary insults activate the release of cellular mediators including proinflammatory cytokines,prostaglandins, free radicals,and complement.The resulting cascade of events avalanche into free radical induced oxidative damage to the br...

Since the dysregulation of ribosome biogenesis is closely associated with tumor progression, in the current study, the critical role of ribosome biogenesis related signaling was investigated in melatonin and/or puromycin induced apoptosis in MDA-MB-231 breast cancer cells. Despite its weak cytotoxicity, melatonin from 3 mM attenuated the expression of 45S pre-ribosomal RNA (pre-rRNA), UBF as a ...

Background and Objective: It has been shown that oxidative stress increases in diabetes and it has an important role in its development and subsequent complications. Thus, the aim of this study was to investigate the effect of acute resistance exercise on oxidative stress in skeletal muscle and cardiac tissues of streptozotocin-induced diabetic rats. Materials and Methods: Twenty male wistar ra...

While daily step counts are considered to be a useful measure of cardiovascular health, the biochemical predictors of step counts have not been fully characterized. This study investigated the correlation between pedometer-determined daily step counts and cardiometabolic variables, including the serum level of malondialdehyde-modified low-density lipoprotein (MDA-LDL), among asymptomatic subjec...

OBJECTIVES To determine the oxidant - antioxidant imbalance in asthmatic children, by measuring the levels of malondialdehyde (MDA) as an oxidant marker of lipid peroxidation as well as antioxidant compounds like vitamin C, vitamin E and uric acid and to investigate whether their concentrations are associated with more severe asthma. METHODS This case controlled prospective study was conducte...

BACKGROUND Semaphorin 4D (Sema4D) is highly expressed in certain types of tumors and functions in the regulation of tumor angiogenesis and growth. However, it is still not clear regarding the roles of Sema4D in breast cancer. This study was designed to explore the effects of Sema4D on proliferation, cell cycle progression, apoptosis, invasion, migration, tumor growth, and angiogenesis in breast...

BACKGROUND Trachoma is the leading infectious cause of blindness worldwide. In communities where the district level prevalence of trachomatous inflammation-follicular among children ages 1-9 years is ≥5%, WHO recommends annual mass drug administration (MDA) of antibiotics with the aim of at least 80% coverage. Population-based post-MDA coverage surveys are essential to understand the effectiven...

current study was aimed to evaluating protective effects of cornus mas fruit extract (cmfe) in mice treated with methotrexate (mtx). for this purpose, 48 young mature male mice were divided into 6 groups. control group received only normal saline (0.1 mlper day, intraperitoneally), and the second group was administered mtx (20 mg kg-1 perweek, intraperitoneally). the third, fourth and fifth gro...