نتایج جستجو برای: mechanical model
تعداد نتایج: 2302625 فیلتر نتایج به سال:
The mechanical origin of polymorphism in two-dimensional tubulin assemblies, including microtubules and other structures such as twisted ribbons, flat sheets, macrotubules, is examined by modeling these anisotropic elastic shells. Varying asymmetries at a dimer level, expressed spontaneous curvature, naturally gives rise to the polymorphic landscape. results provide insight robustness cylindric...
Mechanical force regulates a broad range of molecular interactions in biology. Three types of counterintuitive mechanical regulation of receptor-ligand dissociation have been described. Catch bonds are strengthened by constant forces, as opposed to slip bonds that are weakened by constant forces. The phenomenon that bonds become stronger with prior application of cyclic forces is termed cyclic ...
Dynamic instability of MTs is thought to be regulated by biochemical transformations within tubulin dimers that are coupled to the hydrolysis of bound GTP. Structural studies of nucleotide-bound tubulin dimers have recently provided a concrete basis for understanding how these transformations may contribute to MT dynamic instability. To analyze these ideas, we have developed a molecular-mechani...
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