Overview Humans lose bone mass with age because their bones lose calcium and other minerals and become lighter, less dense and more porous. As this process continues, our bones become weaker, increasing the risk of bone fracture. A patient is said to have osteoporosis when bone mineral density (BMD), the concentration of minerals in a unit volume of bone, falls below a threshold value. Currentl...

BACKGROUND Tibia shaft fractures are among the most common fractures. However, the incidence of tibia fractures does not increase in the elderly. Osteoporotic bone resorption is possibly compensated for by periosteal apposition, which improves the mechanical properties of the bone. The purpose of this study was to identify a correlation between geometric indices of transverse bone scans and rad...

Structural bone allografts are used to reconstruct large skeletal defects resulting from trauma, tumor resection, or revision arthroplasty. Though used for over a century, bone allografts suffer from a high rate of mechanical failure due to limited graft revitalization even after extended periods in vivo. The current study evaluated the mechanical properties of longitudinally perforated cortica...

The study was conducted to test the effect of dexamethasone introduced intramuscularly on volumetric mineral density and physical properties of the femur and humerus in piglets during 14 d of their neonatal life. The effective duration of dexamethasone action lasted together 38 d because sows were treated with dexamethasone during the last 24 d before farrowing. Control piglets were treated wit...

The objective of this study was to examine the effect of embryonic nutritional enrichment on the development and properties of broiler leg bones (tibia and femur) from the prenatal period until maturity. To accomplish the objective, 300 eggs were divided into 2 groups: a noninjected group (control) and a group injected in ovo with a solution containing minerals, vitamins, and carbohydrates (enr...

The proinflammatory cytokine interleukin-1 (IL-1) signals through IL-1 receptor type I (IL-1RI) and induces osteoclastogenesis and bone resorption mainly during pathological conditions. Little is known about the effect of excess or absence of IL-1 signaling on the physiological development of the growth plate and bone. In this study, we examine growth plate morphology, bone structure, and mecha...