although the conventional therapies have obviously improved the conditions of patients with cancer, some mechanisms of resistance have led scientists to use alternative agents that can penetrate in most solid tumors. furthermore, the success of cancer therapies depends on limiting the uptake of toxins to normal tissues and their selectivity to malignant cells. the involvement of natural and gen...

acquired azole resistance in opportunistic fungi causes severe clinical problems in immunosuppressed individuals. this study investigated the molecular mechanisms of azole resistance in clinical isolates of candida glabrata . six unmatched strains were obtained from an epidemiological survey of candidiasis in immunocompromised hosts that included azole and amphotericin b susceptible and azole r...