Accessible online at: www.karger.com/res For many years to come, surgery will remain the only curative treatment for non-small-cell lung cancer in early disease stages, and for as many years, the preoperative staging of mediastinal lymph nodes will remain central to the decision whether a patient should undergo surgery or not. The staging methods have changed considerably with the advent of who...

OBJECTIVE To determine the impact of endoesophageal ultrasound-guided fine-needle aspiration (EUS-FNA) on management of thoracic malignancies. METHODS One hundred and twenty patients referred for invasive diagnostic and resection of thoracic malignancies were studied prospectively. Negative and inconclusive EUS-FNA findings were assessed by video-assisted mediastinoscopic lymphadenectomy (VAM...

BACKGROUND Ultrasound elastography is an imaging procedure that can assess the biomechanical characteristics of different tissues. The aim of this study was to define the diagnostic value of the endobronchial ultrasound (EBUS) elastography strain ratio of mediastinal lymph nodes in patients with a suspicion of lung cancer. The diagnostic values of the strain ratios were compared with the EBUS b...

Pannier and M. 35 Not stated KyphoOsseous and Daems scoliosis cartilaginous (1949) laminae Lloyd (1948) F. 16 9 x 5 Pain Teratoma; thymus present Friedrich F. 21 20 x 18 x Slight Dermal, plain (1942) 12 dyspnoea, muscle intense present pain Dybicki and M. 25 6-5 >' 7 AsymptoDermal, bone Jakubowski x 7-5 matic and teeth (1950) Danis and M. 12 " Orange" Dermoid Govaerts (1942) Bradford, M. 23 8 5...

A 25-year-old man with a rapidly progressive metastatic carcinoid tumour arising in the mediastinum developed a metastasis to the optic nerve. This is the first instance in the literature of an ocular metastasis from this variant of carcinoid tumour. The ocular pathology, ultrastructure, and recent information on the derivation of this tumour, believed to originate in the thymus, are presented.

A mediastinal tumour was simulated by gross dilatation of the azygos vein resulting from compression by enlarged hilar lymph nodes at the point where it crossed the right main bronchus to enter the superior vena cava. This cause of dilatation of the azygos vein has not previously been reported. Published reports are reviewed and attention drawn to the large proportion of patients (11/19) with t...

Secondary transformation in Germ Cell Tumours (GCT) is an extremely rare event. We report here a case of malignant melanoma arising in primary mediastinal GCT. A young male presented with new onset dyspnoea and a mediastinal mass. As serum alpha fetoprotein was raised, a diagnosis of primary mediastinal GCT was made. He achieved remission with standard chemotherapy and resection of the mass. Af...

BACKGROUND Clear cell sarcoma (CCS) is a rare malignant soft-tissue neoplasm that displays melanocytic markers and exhibits striking histopathological features. The tumour has a predilection for the lower extremities and rarely presents in the mediastinum. CASE PRESENTATION We present a case of primary mediastinal CCS in a 57-year-old man. Computer tomography (CT) revealed a 12 × 12 × 7.5 cm ...

Numerous disorders can cause precocious puberty in children, and germ cell tumours (GCT) are one of the rare causes . We report two cases of mediastinal malignant GCTs who presented with precocious puberty. Both patients had bulky and advanced disease, were aggressively treated with neo-adjuvant chemotherapy and surgery, and are surviving and free of disease.

OBJECTIVES It has been shown that increased metabolic activity of primary tumour has a negative effect on survival in non-small cell lung cancer (NSCLC) staged with positron emission tomography integrated computed tomography (PET/CT). We hypothesized that an increased metabolic activity of mediastinal lymph nodes would have worse survival even if it is false. METHODS Three hundred and twenty-...