Programmed cell death ligand 1(PD-L1) is expressed as an adaptive immune response to escape anti-tumor mechanisms in various cancer types, including melanoma. However, the complex regulating PD-L1 expression are not well understood. Our aim elucidate signaling and explore candidate inhibitors C8161, SK-MEL-2 lines (human melanoma) B16(mouse melanoma), LN229(human glioblastoma) were used. RT qPC...

Malignant skin cancers are the most dreadful human neoplasms that pose severe medical and social problems to healthcare sector globally. Skin tumors broadly classified into two major categories namely; melanoma non-melanoma cancer (NMSC).

HIGHLIGHTS Melanoma is a cancer with poor prognosis, and metastasis. Curcumin compound many beneficial effects regarding prevention adjuvant treatment of Vinblastine curcumin greatly promoted production ROS in melanoma cells disrupted adenosine formation cascade, reducing imunosupression at tumoral site.

Melanoma, also called malignant melanoma, is a form of skin cancer triggered by an abnormal proliferation the pigment-producing cells, which give its color. Melanoma one diseases, exceptionally and globally dangerous, Skin lesions are considered to be serious disease. Dermoscopy-based early recognition detection procedure fundamental for melanoma treatment. Early using dermoscopy images improve...

Melanoma is the most aggressive and treatment-resistant of all human skin cancers responsible for approximately 80% cancer mortalities. Melanoma, initiates within epidermis; during progression, cells invade into dermis become primary metastatic through blood vessels lymphatic system. First develop growth occurs by spreading to their draining nodes via vessels, but mechanism not fully understood...

AMA Grzegorczyk A, Marczyńska Z, Matkowski R, et al. Severe complications of nivolumab monotherapy in an adolescent with malignant melanoma. Central European Journal Immunology. 2023. doi:10.5114/ceji.2023.130864. APA Grzegorczyk, A., Marczyńska, Z., Matkowski, R., Ziętek, M., Pietras, W., & Latos-Grażyńska, E. (2023). https://doi.org/10.5114/ceji.2023.130864 Chicago Aleksandra, Zuzanna Rafał M...

Abstract Melanoma is one of the most aggressive and lethal skin cancers. Lucidadiol a triterpenoid isolated from Ganoderma lucidum known to have various biological functions, including antibacterial effects. However, anti-cancer effects mechanism action lucidadiol in malignant melanoma are unknown. In this study, significantly reduced B16 cell viability dose- time-dependent manner. addition, in...

Desmoplastic melanoma(DM) is a subtype of malignant melanoma, and there are very few reports on the occurrence this disease in oral region. Since DM mainly composed achromatic spindleshaped tumor cells, its clinical histopathological diagnoses difficult. However, immunohistochemical staining useful for diagnosis DM.

Several studies have been conducted to explore the anticancer effects of vitamin C (VC). However, effect high-dose VC administration on melanoma is still unknown. Therefore, in this study, we investigated (4 g/kg) invasion and proliferation cells various organs mice. B16 (1 × 106 cells/100 µL) were intravenously injected into tails female mice, solution was orally administered once a day for 14...

The application of metals in biological systems has been a rapidly growing branch science. Vanadium investigated and reported as an anticancer agent. Melanoma is the most aggressive type skin cancer, incidence which increasing annually worldwide. It paramount importance to identify novel pharmacological agents for melanoma treatment. Herein, systematic review publications including “Melanoma Va...