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Alteration in the p53 gene leads to uncontrolled cell proliferation and when these changes accumulate, it may result in carcinogenesis. A plethora of proteins have been reported that bind to the various regions of p53 in order to regulate the specificity of its activity. In the present study, our aim was to understand these connections so we have analyzed the networking role of p53 gene using ‘...

P53 (Tp53, tumor protein p53) is one of the most relevant human oncosuppressor genes. Accordingly, inactivation of p53 by direct mutation of the gene is one of the most frequent genetic lesions in human tumors. In Ovarian Carcinoma (OC), p53 is altered in 30–80% of cases. Molecular and genetic studies have further confirmed the relevance of p53 in the development and progression of OC. Several ...

background: in some studies inflammatory bowel disease (ibd) and celiac disease were considered to be associated and some belive that this association may influence the prognosis of ibd. however, there is a cosiderable controversy regarding this association. therefore ,we aimed to assess the association of these two common digestive diseases and evaluate the complications of this association. m...

background: ischemic heart disease (ihd) is the main cause of morbidity and mortality worldwide, and a considerable part of these patients attend to emergency departments, which increases the burden to these busy departments. the aim of this study was to develop a prediction model enabling prediction of all cause emergency department (ed) visits in patients with documented coronary stenosis in ...

increased susceptibility of birds to avian pathogens in intensive husbandry system has emphasized on necessity of improvement of innate and specific immune responses of birds by the fast establishment of a beneficial microflora and immune stimulator factors to guarantee healthy and low-price products. during this study, 192 one-day-old broiler chicks (ross-380) in four groups with three replica...

IDENTIFICATION OF CELLULAR FUNCTIONS OF CARDIOLIPIN ASPHYSIOLOGICAL MODIFIERS OF BARTH SYNDROMEbyAMIT S. JOSHIDecember 2012 Advisor:Dr. Miriam L. GreenbergMajor:Biological SciencesDegree:Doctor of PhilosophyCardiolipin (CL) is an anionic phospholipid synthesized in themitochondrial inner membrane. Perturbation of CL metabolism leads to Barthsyndro...