El objetivo de este trabajo fue evaluar el efecto bioprotector Croton lechleri L. “sangre grado” frente a la toxicidad del meloxicam en Allium cepa “cebolla”. Se desarrollaron raices 2.5 cm quince bulbos, luego se expusieron durante cuatro horas tres tratamientos: T1 (100 ml agua destilada), T2 (meloxicam 1%), T3 1% mas 20 uL C. lechleri). Las tratadas con exhibieron aberraciones cromosomicas t...

Meloxicam is a non-steroidal antiinflammatory drug from the subgroup of enolic acid oxicams. Meloxicam is a novel NSAID that has effectively replaced the old pain killers particularly diclofenac sodium which has high toxicity. Meloxicam has a high intrinsic activity combined with a low ulcerogenic potential (i.e. a high therapeutic index) (Engelhardt et al., 1996).Meloxicam is considered as sta...

A simple, precise, specific ,robust and rapid HPLC assay for the of measurement meloxicam in pharmaceutical formulations was developed and validated at Department of Pharmacy and Central Quality Assurance Laboratory, LCWU, Lahore. The solution of meloxicam standard was prepared in HPLC grade acetonitrile (5 μg.mL) and ultra sonicated for 15 minutes. One mL sample mixed well with one mL of HPLC ...

The effects of the non-steroidal anti-inflammatory drugs (NSAIDs) on bone quantity and quality were investigated for years. However, there is lack of information on the impact of NSAIDs on the quality of tooth-supporting alveolar bone in absence of periodontal inflammation. Thus, the aim of this study was to evaluate histometrically the influence of a selective COX-2 NSAID (Meloxicam) on the in...

Meloxicam is a non steroidal anti-inflammatory drug, used in the treatment of rheumatoid arthritis and oestoarthritis. It is practically insoluble in water leading to poor dissolution, variations in bioavailability and gastric irritation on oral administration. In order to modulate its gastric side effect and to increase aqueous solubility, physical mixture and solid dispersion of the drug were...

Methods: A total of 162 ninety-day-old pigs showing early clinical signs of PRDC were weighed (Day 0) and allocated into two treatment groups, Controls (n = 82) and Meloxicam (n = 80), in a randomized block design (approximately 20 pigs per pen, four pens per treatment per replicate). In-feed chlortetracycline (800 g per tonne; 20 mg per kg body weight per day) was administered to both groups f...

A double-blind trial was performed on 12 client-owned dogs suffering from acute and painful dermatitis. Clinically these cases represented pyotraumatic dermatitis and pyotraumatic folliculitis. Six dogs were injected with meloxicam and 6 were given placebo. Signs of pain were recorded on a visual analogue scale before administering the drug. This was repeated over the following 2-3 days. All do...

Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most widely used drugs for the management of acute and chronic pain. The role of the opioid system in the synergism between NSAIDs is not well characterized. Mice were injected with a 5% formalin solution (20 μl) into the upper right lip to perform an orofacial formalin test. The isobolographic method was used to determine the interac...

The rate of dissolution of drugs remains one of the most challenging aspects in formulation development of poorly water-soluble drugs. The meloxicam, a low molecular analgetic for oral administration, exhibits a slow dissolution. To improve the dissolution rate, the drug was formulated in a nanosuspension by using an emulsion-diffusion method, high-pressure homogenization or sonication. Optimiz...