Memory T cell populations allow a rapid immune response to pathogens that have been previously encountered and thus form the basis of success in vaccinations. However, the molecular pathways underlying the development and maintenance of these cells are only starting to be unveiled. Memory T cells have the capacity to self renew as do hematopoietic stem cells, and overlapping gene expression pro...

Alzheimer's disease (AD) is known to affect visual pathways, but potential concomitant effects on vision and cognitive performance are not well understood. We studied 43 individuals with AD of mild severity and 22 individuals without dementia on a battery of tests designed to measure multiple aspects of basic and higher-order visual perception and cognition. All subjects performed on the same v...

Background LipiDiDiet is a 6-year, randomized, double-blind, placebo-controlled intervention in 311 individuals with prodromal Alzheimer’s disease (AD)/mild cognitive impairment receiving the specific multinutrient combination Fortasyn Connect (Souvenaid) or calorie-matched placebo control once daily.1 AD characterized by neurodegeneration including significant synapse loss, and hippocampal for...

Infiltration of effector CD8 T cells plays a major role in allograft rejection, and increases in memory and terminally differentiated effector memory CD8 T cells are associated with long-term allograft dysfunction. Alternatively, CD8 regulatory T cells suppress the inflammatory responses of effector lymphocytes and induce allograft tolerance in animal models. Recently, there has been a renewed ...

Genetic approaches have been used to investigate increasingly complex biological systems. Here we review the current state of genetic analysis of learning and memory in the fruitfly, Drosophila melanogaster. Emerging findings support two main themes. First, discovery and manipulation of genes involved with behavioral plasticity in genetically accessible systems such as D. melanogaster enables d...

background and objective: tamoxifen is one of the selective estrogen receptor modulators that exerts estrogen / anti-estrogen effects in various tissues. this study was done to evaluate the effect of chronic administration of tamoxifen on spatial memory and passive avoidance task in adult male wistar rats. methods: in this experimental study, 48 adult male wistar rats were randomly divided into...

objective: this study aimed to investigate the verbal memory and working memory impairment in healthy siblings of patients with schizophrenia.  methods: the purpose of this study was to compare cognitive deficits in siblings of the patients with schizophrenia and control group. a total of 35 unaffected siblings of patients with schizophrenia were selected from the relatives of the patients refe...