SUMMARY Melanocytes are pigment producing cells derived from the neural crest. They are primarily found in the skin and hair follicles, but can also be found in other tissues including the eye, ear and heart. Here, we describe the distribution of pigmented cells in C57BL/6J mouse meninges, the membranes that envelope the brain. These cells contain melanosomes of all four stages of development a...

Pilocytic astrocytomas correspond to low-grade gliomas and therefore metastasize exceedingly rare. However, pilocytic astrocytomas are able to and leptomeningeal dissemination may be seen. What are the treatment options of these cases? We present a case report of a 3-year-old child with a pilocytic astrocytoma of the optic chiasm with leptomeningeal dissemination of the spinal meninges. Partial...

its extent of spread. Being aware that multiple simultaneous CSF leaks are often present, two separate epidurals may lead to a more complete dural tamponade and better sealing in the upper cervical meninges. Injection at two separate sites may decrease the possibility of spinal compression from a large amount of blood and guarantee a more uniform distribution over the meninges. In conclusion, s...

We describe the case of a 54-year-old woman with a clinical diagnosis of Churg-Strauss syndrome (CSS). The patient had a fever of unknown origin, severe headache, progressing left ophthalmoplegia, and visual acuity disturbance. MR imaging revealed diffuse and thick hypointense lesions on T2-weighted images in the frontal meninges and anterior falx cerebri with diffuse enhancement. Similar lesio...

In 1979 my laboratory published its first article on migraine in The Lancet, and it was entitled “Neurotransmitters and the fifth cranial nerve: Is there a relation to the headache phase of migraine?”1 In this article, we hypothesized that the trigeminal nerve was a critical component in the pathogenesis of migraine. At that time, the sensory innervation to the blood vessels of the circle of Wi...

Clinical, pathomorphological and immunohistological findings of generalised tuberculosis diagnosed in a 1-year-old male tabby cat were evaluated. Macroscopic examination revealed greyish-white nodules, exceeding the surface of the organ, in the meninges and kidneys. The meninges nodules were of the size of a pinhead and those in the kidneys were 0.2-0.5 cm in diameter. The mediastinal lymph nod...