A dietary combination of sucrose and linoleic acid strongly contributes to the development of metabolic disorders in Zucker fatty rats. However, the underlying mechanisms of the metabolic disorders are poorly understood. We hypothesized that the metabolic disorders were triggered at a stage earlier than the 8 weeks we had previously reported. In this study, we investigated early molecular event...

Introduction Metabolic syndrome (METS) represent a simultaneous presence of multiple metabolic disorders in one person. Prevalence is increasing worldwide, which is probably related to increased obesity and sedentary lifestyle. Non-alcoholic steatosis or "fatty liver" is a metabolic disease caused by fat dysfunction. It can be a sign of some other disease, and can often be found in patients wit...

• Tetrahydrocurcumin (THC) improves glucose and lipid metabolism disorders in nonalcoholic fatty liver disease (NAFLD) mice. THC regulates the expression of oxidoreductase genes lipid-metabolizing enzyme NAFLD increases antioxidant capacity inhibits deposition HepG2 cells by activating NRF2 signaling pathway. Nonalcoholic is most common metabolic world. In this study we investigated effect tetr...

Abstract Currently, there are no effective therapies for intestinal and hepatic fibrosis representing a considerable unmet need. Breakthroughs in pathogenesis have accelerated the development of anti‐fibrotic therapeutics recent years. Particularly, with nanotechnology, harsh environment gastrointestinal tract inaccessible microenvironment fibrotic lesions seem to be longer considered great bar...

the present study has been directed to investigate ursodeoxycholic acid (udca) effect in children, to reduce the high liver transaminases induced by anticonvulsant drugs (drug induced hepatitis). this idea has been driven from cytoprotective and antioxidant properties of udca to be used in drug induced inflammation in liver. twenty two epileptic patients aged between 4 mo - 3 yr whom were under...

Metabolic disorders induced by endocrine disruptors (ED) may contribute to amphibian population declines but no transgenerational studies have evaluated this hypothesis. Here we show that Xenopus tropicalis, exposed from the tadpole stage, ED benzo[a]pyrene (BaP, 50 ng.L−1) produced F2 progeny with delayed metamorphosis and sexual maturity. At adult F2–BaP females displayed fatty liver inflamma...

Excessive accumulation of lipids can lead to lipotoxicity, cell dysfunction and alteration in metabolic pathways, both in adipose tissue and peripheral organs, like liver, heart, pancreas and muscle. This is now a recognized risk factor for the development of metabolic disorders, such as obesity, diabetes, fatty liver disease (NAFLD), cardiovascular diseases (CVD) and hepatocellular carcinoma (...

GH and sex hormones are critical regulators of body growth and composition, somatic development, intermediate metabolism, and sexual dimorphism. Deficiencies in GH- or sex hormone-dependent signaling and the influence of sex hormones on GH biology may have a dramatic impact on liver physiology during somatic development and in adulthood. Effects of sex hormones on the liver may be direct, throu...