The metabolic syndrome (MS) recognized as a major cause of type 2 diabetes and cardiovascular diseases, has become one of the major public health challenges worldwide. The pathogenesis of the metabolic syndrome is multiple and still poorly understood. No single factor has yet been identified as an underlying causal factor. There is a growing belief, however, that obesity, especially visceral ob...

introduction: transient hyperglycemia is a condition that happens during acute physiologic stress in children.  the aim of this study is to determine if there is any relation between stress hyperglycemia and diabetes mellitus and metabolic syndrome in pediatric patients.   materials and methods:  the study was performed on children hospitalized in amirkola pediatric hospital, north of iran, bet...

Metabolic syndrome is a cluster of metabolic disorders that increase the risk of cardiovascular diseases, which includes type 2 diabetes, elevated blood pressure, and atherogenic dyslipidemia. Studies have shown that oxidative stress plays an important role in the etiology of cardiovascular diseases, as well as diabetes and its complications. Antioxidants provide protection from these chronic d...

OBJECTIVE Systemic oxidative stress causes insulin resistance in rodents. We tested the hypothesis that oxidative stress and insulin resistance are associated in humans. RESEARCH DESIGN AND METHODS We used cross-sectional data from 2,002 nondiabetic subjects of the community-based Framingham Offspring Study. We measured insulin resistance with the homeostasis model and defined categorical ins...

The development of metabolic syndrome is closely associated with the deregulation of lipid metabolism. Emerging evidence has demonstrated that microRNAs (miRNAs) are intensively engaged in lipid and lipoprotein metabolism by regulating genes involved in control of intracellular lipid synthesis, mitochondrial fatty acid oxidation, and lipoprotein assembly. Mitochondrial dysfunction induced by al...

Free radicals are normally produced by living organism, at controlled production rate they perform physiological functions as signal transduction molecules. However, situations leading to an overproduction that surpasses antioxidant capacity creates oxidative stress. Consequently, damage to the cell membrane, protein, DNA and cell death are observed. Dairy cattle are susceptible to oxidative st...

melas syndrome is a mitochondrial disorder with progressive nature, because adequate treatment is not available. diagnosis of this mitochondrial disorder depends initially on clinical suspicion, which is strengthened by additional metabolic evidence of impaired oxidative metabolism such as high serum or c.s.f. lactate levels and confirmed by demonstration of mitochondrial abnormalities-in muscl...

The presence of the metabolic syndrome (World Health Organization definition) and its association with lipoprotein abnormalities suggestive of greater susceptibility to oxidative stress have been analyzed in patients with angiographically defined coronary artery disease. The odds ratio for the presence of the metabolic syndrome was significantly higher in coronary artery disease-positive patien...