Acute leukemia is a critical neoplasm of white blood cells. In order to differentiate between the metabolic alterations associated with two subtypes of acute leukemia, acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML), we investigated the serum of ALL and AML patients and compared with two controls (healthy and aplastic anemia) using (1)H NMR (nuclear magnetic resonance) spect...

The aim of this study was to establish an experimental model for metabonomic profiles of the rat's brain and then to investigate the antidepressant effect of Banxia Houpu decoction (BHD) and its possible mechanisms. Behavioral research and metabonomics method based on UPLC-MS were used to assess the efficacy of different fractions of BHD on chronic unpredictable mild stress (CUMS) model of depr...

Abstract Objectives To reveal the compatibility mechanism and material basis of Danggui Buxue decoction (DBD) against anaemia. Methods UHPLC-Q-Exactive-MS based serum metabonomics was applied to decipher DBD anaemia mice. Meanwhile, network pharmacology used on obtained differential metabolites. Key findings Metabonomic results indicated that 17 metabolites were closely related DBD, Huangqi (HQ...

1.3. Statistical analysis & Expert systems in toxicological screening: 1-9 1.3.1. CLOUDS-Overlap 1-10 1.3.2. SMART scaling 1-12 1.3.3. Commonly used terms in statistical pattern recognition 1-12 1.3.3.1. Cross-validation 1-12 1.3.3.2. Classification vs. regression 1-12 1.3.3.3. Supervised vs. unsupervised methods 1-13 1.3.4. Pattern recognition techniques 1-13 1.3.5. Principle component analysi...

The aim of the research was to investigate metabolic variations associated with genetic modifications in the grains of Zea mays using metabonomic techniques. With this in mind, the non-targeted characteristic of the technique is useful to identify metabolites peculiar to the genetic modification and initially undefined. The results obtained showed that the genetic modification, introducing Cry1...

Acupoint stimulations are effective in ameliorating symptoms of menopause which is an unavoidable ageing consequence for women. To understand the mechanistic aspects of such treatments, we systematically analyzed the effects of acupoint laser-irradiation and catgut-embedding on the ovariectomy-induced rat metabolic changes using NMR and GC-FID/MS methods. Results showed that ovariectomization (...

The effects of tumorigenesis and tumor growth on the non-involved organs remain poorly understood although many research efforts have already been made for understanding the metabolic phenotypes of various tumors. To better the situation, we systematically analyzed the metabolic phenotypes of multiple non-involved mouse organ tissues (heart, liver, spleen, lung and kidney) in an A549 lung cance...

A metabonomic study was performed to investigate the metabolic mechanism of essential hypertension and its Chinese medicine subtypes, including "Yin-deficiency and Yang-hyperactivity syndrome" (YDYHS) and "Yin-Yang deficiency syndrome" (YYDS). Plasma samples from 22 healthy volunteers, 31 hypertensive patients with YDYHS, and 29 hypertensive patients with YYDS were analyzed by (1)H-NMR spectros...