نتایج جستجو برای: metalloproteinase
تعداد نتایج: 20510 فیلتر نتایج به سال:
The main objective of this study was to assess the in vitro effects of curcuminoids extract, hydrolyzed collagen and green tea extract in normal bovine chondrocytes and osteoarthritic human chondrocytes cultured in monolayer. This study also investigated the synergic or additive effects of these compounds. Enzymatically isolated primary bovine or human chondrocytes were cultured in monolayer un...
MMP-11 is a key factor in physiopathological tissue remodeling. As an active form is secreted, its activity must be tightly regulated to avoid detrimental effects. Although TIMP-1 and TIMP-2 reversibly inhibit MMP-11, another more drastic scenario, presumably via hydrolysis, could be hypothesized. In this context, we have investigated the possible implication of MMP-14, since it exhibits a spat...
Citation: Bencsik P, Kupai K, Görbe A, Kenyeres É, Varga ZV, Pálóczi J, Gáspár R, Kovács L, Weber L, Takács F, Hajdú I, Fabó G, Cseh S, Barna L, Csont T, Csonka C, Dormán G and Ferdinandy P (2018) Development of Matrix Metalloproteinase-2 Inhibitors for Cardioprotection. Front. Pharmacol. 9:296. doi: 10.3389/fphar.2018.00296 Development of Matrix Metalloproteinase-2 Inhibitors for Cardioprotection
BACKGROUND AND PURPOSE The pathophysiology of cerebral aneurysms (CAs) is linked to chronic inflammation and degradation of extracellular matrix in vascular walls. Because statins have protective effects on various vascular diseases independent of their lipid-lowering effects, we investigated the effect of simvastatin on CA progression. METHODS CAs were induced in Sprague-Dawley rats with or ...
The lung cancer is one of the most dangerous cancers and is also the leading cause of cancer death worldwide, accounting for about 1.3 million deaths annually. However in clinical practice, lung cancer therapies commonly do with chemotherapy, although it is hard because the lung cancer may progress to metastasis stage. The metastasis of lung cancer is highly dependent of expression of matrix me...
Background Astragalus polysaccharide (APS) had shown great promise in anti-tumour activities our previous studies. The present study was designed to investigate whether APS has synergistic effect with cisplatin on the growth-inhibitory of human nasopharyngeal carcinoma cell lines and possible mechanism. Methods Here, (CNE-1) were divided into CNE-1 group, Cisplatin treatment group (2 µg/mL Cisp...
Introduction. Reintervention in patients with spinal disk herniation is shown to significantly decrease likelihood of favorable outcomes the postoperative period. Thus, it important individually assess risk factors for and recurrence each patient, choose a suitable surgical option.
 Objective: evaluate changes levels immunoregulatory mediators blood serum extracted disc tissue allegedly he...
It is evidently known that chronic inflammatory process in the bronchi of patients with bronchial asthma associated emergence and progression airway remodeling, resulting irreversible obstruction. However, exact mechanisms connection between inflammation remodeling are not very well understood reason for delay development new specific targeted drugs aimed to inhibit remodeling. Therefore, our g...
the biological mechanisms of tooth movement are based on the response of periodontal tissues to mechanical forces. the final result of these responses is remodeling of the extracellular matrix. tissue reactions may vary depending upon the type, magnitude and duration of the applied forces. the purpose of the present study was to analyze the effects of centrifugal force on the transcription of c...
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