The aureolic acid antibiotic mithramycin (MTM) binds selectively to GC-rich DNA sequences and blocks preferentially binding of proteins, like Sp1 transcription factors, to GC-rich elements in gene promoters. Genetic approaches can be applied to alter the MTM biosynthetic pathway in the producing microorganism and obtain new products with improved pharmacological properties. Here, we report on a...

BACKGROUND: The medication therapy management (MTM) program identified high-risk members in a large employer group and invited them to participate in an MTM program. The intervention consisted of at least 3 consultations with a clinical pharmacist to review and discuss drug therapy. The goal was to improve drug therapy adherence and clinical outcomes. OBJECTIVE: To assess the impact of MTM on p...

OBJECTIVE To determine the direct financial impact for patients resulting from Medication Therapy Management (MTM) interventions made by community pharmacists. Secondary objectives include evaluating the patient and physician acceptance rates of the community pharmacists' recommended MTM interventions. METHODS This was a retrospective observational study conducted at 20 Price Chopper and Hen ...

We explore the relationship between multiple team membership (the extent to which team members are engaged in more than one team and switch between different teams in a work day) and team performance. We argue that the number of MTMs has an inverted U-shaped relationship with team performance while the team average daily MTM is negatively related to performance. We propose that the use of colla...

Cells rely on the coordinated regulation of lipid phosphoinositides and Rab GTPases to define membrane compartment fates along distinct trafficking routes. The family of disease-related myotubularin (MTM) phosphoinositide phosphatases includes catalytically inactive members, or pseudophosphatases, with poorly understood functions. We found that Drosophila MTM pseudophosphatase Sbf coordinates b...

The effects of three concentrations (0.2%, 1% and 3%) of rosemary oil (RO) on the freshness indicators, oxidative stability, fatty acid and biogenic amine (BA) contents of minced rainbow trout muscle (MTM) were investigated after different periods of storage (three and nine days) at 4 ± 1 °C. Moreover, the terpene and sesquiterpene contents in the treated MTM were also measured. RO treatment im...

Commercially manufactured New York City (NYC) medium and modified Thayer-Martin (MTM) medium were compared for their ability to isolate Neisseria gonorrhoeae from clinical specimens. Twenty-seven public health laboratories throughout California evaluated 4,802 specimens collected from patients attending either sexually transmitted disease or family planning clinics. Total of 726 and 737 N. gono...

A new compact ultrawideband (UWB) patch antenna based on the resonance mechanism of a composite right/left-handed (CRLH) transmission line (TL) is proposed. The radiating element of the antenna is made from three left-handed (LH) metamaterial (MTM) unit cells placed along one axis, where each unit cell combines a modified split-ring resonator (SRR) structure with capacitively loaded strips (CLS...

Modern wireless devices, such as those that implement the 802.11b standard, utilize multiple transmission rates in order to accommodate a wide range of channel conditions. Traditional ad hoc routing protocols typically use minimum hop paths. These paths tend to contain long range links that have low effective throughput and reduced reliability in multi-rate networks. In this work, we present th...

The myotubularin (MTM) family constitutes one of the most highly conserved protein-tyrosine phosphatase subfamilies in eukaryotes. MTM1, the archetypal member of this family, is mutated in X-linked myotubular myopathy, whereas mutations in the MTM-related (MTMR)2 gene cause the type 4B1 Charcot-Marie-Tooth disease, a severe hereditary motor and sensory neuropathy. In this study, we identified a...