Cancers evolve as a result of the accelerated proliferation cancer cells in complicated, enriched, and active microenvironment. Tumor microenvironment (TME) components are master regulators any step development. The tumor is composed many cellular noncellular that contribute to evolution cells. Cancer-associated fibroblasts (CAFs) activated TME implicate progression metastasis dissemination thr...

background: colorectal cancer is the third cause of cancer death in western countries. age, inadequate diet, obesity, inactivity and genetic changes are some of the risk factors of colorectal cancer. correlation of genetic diversity in homologous recombination repair system with cancer was evaluated in many recent studies. this study was done to investigate the correlation of t241m polymorphism...

background: triple negative breast cancer (tnbc) is reported to be associated with a high risk of recurrence, poor overall survival (os), and disease-free survival (dfs) rates. this study evaluated the clincopathological features and survival of non-metastatic tnbc women in the capital of iran compared with other areas of the world. methods: in a retrospective study, 119 women with tnbc based o...

background: the aim of this study was to detect prognostic factors in recurrent breast cancer metastasis. materials and methods: th is retrospective cohort study employed data from 996 breast cancer patients of isfahan seyed-o-shohada research center from 1998 to 2010. stratifi ed cox proportional hazards model, marginal approach, was used to evaluate the prognostic value of estrogen receptor, ...

Lung Cancer Metabolic reprogramming is a hallmark of metastatic lung cancer cells (A549_3R). In article number 2200050, Victor Shahin and co-workers establish that 5-7 carbon glycols reduce the A549_3R ATP production by interfering with LDH mitochondria. The cover image reveals decline in mitochondrial membrane potential when exposed to 1,6-HD.

The article describes clinical observation of locally advanced metastatic anaplastic thyroid cancer. Difficulties in instrumental and laboratory diagnosis this pathology the role molecular search for highly effective treatment are discussed.

Cancer Immunotherapy In article number 2301789 by Qiuyun Li, Gang Ji, Guodong Yang, and co-workers, a modular hydrogel based vaccine system is developed. combination with sonodynamic therapy, the efficiently inhibits tumor growth metastasis via diverting TdLN metastatic cancer to hydrogel, killing trapped cells, eliciting prolonged powerful immunotherapy in sequential orchestrated manner.

Effective treatment for metastatic prostate cancer is critically needed. The present study was aimed at identifying metastasis-driving genes as potential targets for therapy (oncotargets). A differential gene expression profile of metastatic LTL-313H and non-metastatic LTL-313B prostate cancer tissue xenografts, derived from one patient's specimen, was subjected to integrative analysis using th...

background: cd4+ and cd8+ t cells are the main types of lymphocytes in cell-mediated immunity and play a central role in the induction of efficient immune responses against tumors. the frequencies of t cell subtypes in the peripheral blood and tumor tissues, and draining lymph nodes (dln) can be considered as useful markers for evaluation of the immune system in cancers. methods: in this study,...

Colorectal cancer (CRC) metastasis to the thyroid gland is rare. Here wereport a 45 yr-old man in western Iran referred to Hematology Clinic, Kermanshah city, Iran in March 2014 with complaint of exertional dyspnea, multi-nodular goiter as well as complaint of exertional dyspnea, and multi-nodular goiter. His history included a low anterior resection of rectum in 9 months ago for a high-risk st...