BACKGROUND Small molecules that inhibit V600 mutated BRAF protein, such as vemurafenib and dabrafenib, are effective in treatment of metastatic melanoma. CASE REPORT We here describe the clinical course of a V600E BRAF mutated metastatic melanoma patient with systemic disease, who developed tumor progression on superficial soft-tissue metastases during treatment with dabrafenib. Bleomycin ele...

Melanoma is a tumor of pigment producing cells melanocytes. Malignant melanoma is associated with a high morbidity and mortality because of its widespread and rapid metastasis. Melanoma commonly metastasizes to lung and secondary metastatic pulmonary melanoma is a well known entity. Metastatic melanoma can present with varied pattern of pulmonary involvement ranging from post obstructive pneumo...

BACKGROUND The incidence of malignant melanoma (MM) was occurring at a faster rate than for most neoplasm worldwide, and melanoma metastasis is still the most formidable problem. So it is necessarily to find some biomarkers associated with melanoma metastasis. METHODS In our study, 8 spontaneous lung metastatic mice models were created by B16F10 subcutaneously transplantation. The differentia...

Melanoma is a leading cause of cancer deaths worldwide. Although targeted therapy and immunotherapy have improved the outcome patients with metastatic disease, unwanted side effects are problem. Herein, by using human melanoma cell lines in vitro, we explore that melatonin enhances anti-tumor activity commonly used BRAF/MEK inhibitors, i.e. vemurafenib (VF) cobimetinib (CB), respectively. Our r...

This dissertation is based on the following publications on metastatic uveal melanoma. The original publications in the text will be referred to by their Roman numerals I-IV: doubling times in metastatic malignant melanoma of the uvea: Tumor progression before and after treatment. prognostic model and staging for metastatic uveal melanoma.

Background. Visceral metastatic spread of ocular melanoma most commonly occurs via hematogenous route to the liver. Lymphatic spread of ocular melanoma into abdominal lymph nodes has not been reported previously. Case Presentation. A 47-year-old man with a history of ocular melanoma presented with a soft tissue mass on CT scan. The mass encased the portal structures of the hepaticoduodenal liga...

Tumor suppressor gene O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation has been reported in melanoma. However, the clinical and prognostic significance of MGMT promoter methylation in patients with melanoma remained to be determined. A systematic search was performed to identify eligible papers published. The overall odds ratios (ORs) or hazard ratios and their 95% confidence ...

Metastasis is a key factor that limits survival in the majority of patients with cancer. Thus, numerous efforts have been made to elucidate the molecular mechanisms involved in this phenomenon. B16‑F10 melanoma cells have been demonstrated to be highly metastatic to the lungs in mice. The aim of the current study was to investigate the role of CXC motif chemokine receptor 4 (CXCR4) in the metas...

In this study the relationship between tissue-type transglutaminase (TGase2) activity and the propensity to metastasize was investigated in human melanoma cell lines with different metastatic behavior. TGase2 catalyzes an acyl-transfer reaction between peptide-bound glutamine residues and primary amines, including the epsilon-amino group of lysine residues. Northern-blot analysis demonstrated t...

Clinical reports of primary sphenoid sinus melanoma and isolated gastric metastatic melanoma are rare. Thus, to the best of our knowledge, the present study reports the first case of isolated gastric metastasis from a sphenoid sinus melanoma. The aim of the present study was to discuss the clinicopathological and radiographic characteristics, the treatment strategy and the prognosis of sphenoid...