Shortly after the first white settlers crossed through the Cumberland Gap into the western foothills of the Appalachians there arose in one kinship several particu­ larly swarthy offspring characterized by deep bluish skin coloration. These folks — the Blue Fugates — apparently suffered no ill effects of this condition and indeed numerous off-spring were bom some of which also had this peculiar...

OBJECTIVES To see if methemoglobin could potentially be misdiagnosed and the limitation of present cooximeters. PATIENT A 17-year-old girl who overingested a combination of cimetidine, acetaminophen, ibuprofen, and naproxen in a suicide attempt. METHOD Use of pulse co-oximeters to aid in the diagnosis of suspected sulfhemoglobinemia. RESULTS Diagnosis of sulfhemoglobinemia achieved with f...

Human blood was infused through a gas permeable membrane to determine if treatment with nitric oxide affects the signal intensity of its T1-weighted magnetic resonance image. Equal volumes of blood with increasing concentrations of methemoglobin were placed in glass tubes. T1-weighted images of the samples were obtained with a 1.5T magnetic resonance scanner. There was a linear correlation betw...

The mechanism by which superoxide anion is generated by the interaction of phenylhydrazine with either oxy- or methemoglobin was investigated. Rather than superoxide anion generation resulting from an accelerated autooxidation of oxyhemoglobin, it was found that both oxy- and methemoglobin function as peroxidases toward phenylhydrazine with the resultant oxidation of this compound to phenyldiaz...

background: hydrogen sulfide (h 2 s) exhibits both physiological and toxicological roles in the biological systems. acute exposure to high levels of h 2 s is life threatening while long-term exposure to ambient levels of h 2 s elicits human health effects. objective: to study the harmful effects of long-term exposure to low levels of h 2 s on human blood cells. methods: 110 adult workers from i...

Methemoglobinemia is a dyshemoglobinemia characterized by cyanosis and reduced oxygen saturation with increased methemoglobin values. The etiology may be congenital or acquired, the latter being more common. We report case of full-term neonate who presented transient methemoglobinemia caused mutation in gamma chain fetal hemoglobin.