A 40-year-old woman was admitted due to an urticarial rash that was attributed to recent onset of methimazole treatment for a diagnosis of Grave's disease. The patient had no prior significant medical history and used no medications, including over-the-counter or herbal medications. Her sister had Grave's disease. On admission, the patient received corticosteroids with improvement in her rash. ...

Ten hypothyroid patients with Hashimoto's thyroiditis were treated with methimazole 30 mg in addition to thyroxine 0.15 mg daily. Another 10 hypothyroid patients with Hashimoto's thyroiditis were given thyroxine 0.15 mg alone. After 22 weeks of treatment significant decreases in thyroid microsomal autoantibody titres were observed in both groups (p less than 0.01). There was no difference in th...

Introduction: Thyroid hormones play an important role in the regulation of metabolism, maturity and reproduction. Thyroid dysfunction affects almost all endocrine glands such as pituitary and testis. The aim of this study was to investigate alterations of testosterone and luteinizing hormone (LH) serum levels as well as weights of thyroid gland and testes in methimazole (MMI)-induced hypothy...

The specificities of orphenadrine and methimazole on eight human liver P450 enzyme activities were evaluated by studying the extent of inhibition at different concentrations in two protocols: competitive inhibition and preincubation. In the competitive inhibition protocol, orphenadrine decreased CYP2B6 marker activity up to 45– 57% in human liver microsomes and up to 80–97% in cell microsomes c...

Keywords Adverse Drug Reactions (334, 347), Amoxicillin (348), Antipsychotics (330), Beta Lactams (331), Cancer Treatments (354), Chemotherapy (351), Cough Medication (352), COVID Vaccine (349, 353, 358), Creatine (339), Daptomycin (336), Drugs (332, 337, 340), Hand Sanitizers (335), Ibuprofen (344), Immune Checkpoint Inhibitors (357), Methimazole (350), Methylprednisolone (333), Metoclopramide...

Agranulocytosis is a phrase often used to indicate severe neutropenia. It rare, but serious adverse effect of anti-thyroid medications with prevalence less than one percent. Diagnosis warrants immediate termination the offending agent, in addition prompt evaluation for definitive treatment options. Due low prevalence, presentation can pose diagnostic and challenge. We present case 21-year-old f...

In this study, the effect of supplementation with a fixed combination of antioxidants (vitamins C and E, beta-carotene and selenium) on concentrations of antioxidative parameters in serum was monitored. Measurements were performed prior to the commencement of therapy and after 30 and 60 days in patients with Graves' disease treated with methimazole. Patients who received extra supplementation w...