The objective of this study was to determine the optimum ratio of methionine to methionine plus cystine for growing pigs. A nitrogen balance trial was conducted using a total of 21 barrows (Large White×Landrace) over two replicates. The initial body weight was 20.36±1.22 kg (mean±SD) in the first replicate and 23.54±1.02 kg (mean±SD) in the second. For each replicate, the 21 pigs were randomly ...

The underlying cause(s) of methionine-dependency and its relevance to cancer remains unclear. We aimed to determine whether (i) normal human lymphocytes exhibit methionine-dependency, (ii) baseline levels of genetic damage are related to methionine-dependency and (iii) methionine-dependence can be explained, in part, by common polymorphisms in methionine synthase and methylenetetrahydrofolate r...

The transport of l-methionine by the gram-positive species Brevibacterium linens CNRZ 918 is described. The one transport system (K(m) = 55 muM) found is constitutive for l-methionine, stereospecific, and pH and temperature dependent. Entry of l-methionine into cells is controlled by the internal methionine pool. Competition studies indicate that l-methionine and alpha-aminobutyric acid share a...

D-methionine was administered intraperitoneally to rats in tracer (22.5 pmoles/kg) and large doses (4.7 mmoles/kg) and the brain levels of total (D + L) methionine, as well as of cysteine (+cystine) and glutathione were determined. The effect of co-administering the convulsant agent, L-methionine-DL-sulfoximine (MSO) was also examined. The administration of tracer doses of Cl2-D-methionine resu...

An experiment was conducted to evaluate the effect lysine and methionine supplementation low protein diet on production performance serum biochemical parameters in Vanaraja laying hens. One hundred twenty (n=120), 30-weeks old hens were randomly distributed into four dietary treatments with three replicates each group having 10 birds replicate. Four diets formulated 2600 kcal/kg of metabolizabl...

A 2×5 factorial experiment, using 2 dietary methionine levels (0.28% and 0.48%) and 5 dietary choline levels (0, 394, 823, 1,239, and 1,743 mg/kg), was conducted to study the effects of dietary methionine status on choline requirements of starter white Pekin ducks from 7 to 28 days of age. Four hundred eighty 7-d-old male White Pekin ducks were randomly allotted to ten dietary treatments, each ...

To determine the rates of methionine splanchnic uptake and utilization in critically ill pediatric patients we used two kinetic models: the plasma methionine enrichment and the "intracellular" homocysteine enrichment. Twenty four patients, eight infants, eight children, and eight adolescents, were studied. They received simultaneous, primed, constant, intravenous infusions of l-[(2)H(3)]methylm...