BACKGROUND The testes have been considered a sanctuary site for leukemic cells and testicular relapses used to account for a major proportion of the poor outcome of boys with acute lymphoblastic leukemia. With use of aggressive chemotherapy which includes intermediate or high dose methotrexate, the incidence of testicular relapses has declined. However once these patients have received cranial ...

Abstact：objective To investigate acute kidney injury (AKI) in children with acute lymphoblastic leukemia (ALL) who received high dose methotrexate (MTX) chemotherapy and explore the corresponding treatment. Methods 180 children who received high dose MTX chemotherapy were observed with serum MTX concentration and serum creatinine. Patients with AKI of stage 3 or poor response to conventional tr...

Abstact：objective To investigate acute kidney injury (AKI) in children with acute lymphoblastic leukemia (ALL) who received high dose methotrexate (MTX) chemotherapy and explore the corresponding treatment. Methods 180 children who received high dose MTX chemotherapy were observed with serum MTX concentration and serum creatinine. Patients with AKI of stage 3 or poor response to conventional tr...

The advancement and intensive use of chemotherapy in treating childhood cancers has led to a growing population of young cancer survivors who face increased bone health risks. However, the underlying mechanisms for chemotherapy-induced skeletal defects remain largely unclear. Methotrexate (MTX), the most commonly used antimetabolite in paediatric cancer treatment, is known to cause bone growth ...

An 11-year-old boy with acute lymphoblastic leukemia had received prophylactic cranial irradiation (1800 cGy /10 fractions) and intrathecal methotrexate. Five years later, he developed a glioblastoma multiforme in the right frontal region while the leukemia was in remission. It is possible that the glioma may have been induced by radiation and /or chemotherapy.

E98 Comparison of Doxorubicin Versus VP16-Ifosfamide in Addition of High Dose Methotrexate as Pre-operative Chemotherapy in Osteosarcomas. A Randomized Trial by the French Society of Pediatric Oncology L.B. Brugieres1, C. Kalifa1, J.M. Guinebretiere1, J.C. Gentet2, T. Philip3, N. Dupouy1, N. Bellon1, C. Rodary1 1Institut Gustave Roussy, Villejuif, France, 2Hospital La Timone, Marseille, France,...

To cite this Article: Yamanaka, Ryuya, Homma, Junpei, Sano, Masakazu, Tsuchiya, Naoto, Yajima, Naoki, Shinbo, Yoshikatsu, Hasegawa, Akira, Onda, Kiyoshi and Tanaka, Ryuichi , 'Immuno-chemotherapy with a combination of rituximab, methotrexate, pirarubicin and procarbazine for patients with primary CNS lymphoma A preliminary report', Leukemia and Lymphoma, 48:5, 1019 1022 To link to this article:...

The “state-of-art” treatment approach for patients with metastatic urothelial cancer (eg, bladder or other tumors of urinary tract) is platinum-containing chemotherapy, however, despite the high immediate efficacy therapy (up to 70% objective response rate), long-term results remain unsatisfactory, median progression-free and overall survival usually do not exceed 6 12 months respectively, visc...

The most important advance in primary central nervous system (CNS) lymphoma treatment has been the convincing data that high-dose methotrexate-based chemotherapy regimens improve survival compared to historical controls treated with radiotherapy alone. However, the optimal treatment approach is still unclear and therapy can be associated with long-term neurotoxicity. Current research focuses on...

A combination of systemic chemotherapy, feticide with intrachest and intra-abdominal injection with methotrexate, and hysteroscopy with dilation and curettage to remove the gestational tissue was successful in the treatment of a cesarean scar ectopic pregnancy. This case presents images of the ultrasound, magnetic resonance imaging, and pathologic features unique to a cesarean scar pregnancy.