A library of thirty novel thiazolo[5,4-f]quinazolin-9(8H)-one derivatives belonging to four series designated as 12, 13, 14 and 15 was efficiently prepared, helped by microwave-assisted technology when required. The efficient multistep synthesis of methyl 6-amino-2-cyano- benzo[d]thiazole-7-carboxylate (1) has been reinvestigated and performed on a multigram scale. The inhibitory potency of the...

Chronic granulomatous disease (CGD) is a congenital disorder characterized by severe and recurrent infections, including pneumonia and deep tissue abscesses, leading to early death from sepsis. (Curnutte and Babior 1987). Two forms of inheritance have been noted. Most cases (80-90%) show X-linked transmission, with the remaining cases being autosomal recessive. Both forms have in common a defic...

Nitroblue tetrazolium test scores were obtained in 43 patients with psoriatic arthritis, 32 patients with rheumatoid arthritis, and 16 patients with osteoarthrosis. The mean score in all groups was similar and was higher than previously reported in patients awaiting heart surgery or with noninfective dermatoses. The test is not thought to be helpful in differentiating psoriatic arthritis from r...

introduction: escherichia coli is one of the important pathogens in human with global importance. because of the necessity for identification and the use of novel antibacterial compounds against e. coli , in this present study we focused on the antibacterial effects of synthesized thiazole, imidazole and tetrahydropyridine derivatives on e. coli .   methods : for evaluation of antibacterial eff...

 The synthesis in water of new sulfone derivatives under microwave irradiation is described. This eco-friendly process leads to the expected products in good yields by reaction of various substituted sulfinates (commercially available or obtained by reduction of the corresponding sulfonyl chlorides) with 4-chloromethyl-2-methyl-5-nitro-1,3-thiazole. In order to evaluate the antiproliferative ef...

The nitroblue tetrazolium (NBT) test has been evaluated as a means of differentiating episodes of infection and rejection in 10 cadaver kidney transplant recipients. Normal NBT values were observed during all 11 episodes of acute rejection. A significant elevation of the NBT score was encountered in six of eight episodes of infection after transplantation. A positive NBT result is useful additi...

Reduction of triphenyltetrazolium chloride (TTC) by tissue to the red-colored insoluble triphenylformazan (TF) is directly linked to the activity of the mitochondrial respiratory chain. Thus, only living tissues should reduce TTC to TF. However, TF production can be detected when the TTC test is applied to control tissues boiled in water. This artifact is mainly the result of the hot ethanol ex...

OBJECTIVE To assess the neutrophil function in thalassemia major (TM) patients and compare it with the control group, and to recognize its relevant factors. METHODS This was a retrospective cohort study, which was carried out from October 2007 to February 2008 in the Thalassemia Research Center in Boo Ali Sina Hospital in Sari, Mazandaran, north of Iran. The study population consisted of TM p...