نتایج جستجو برای: methylenetetrahydrofolate reductase deficiency
تعداد نتایج: 180150 فیلتر نتایج به سال:
Dynamical modeling is an accurate tool for describing the dynamic regulation of one-carbon metabolism (1CM) with emphasis on the alteration of DNA methylation and/or dUMP methylation into dTMP. Using logic programming we present a comprehensive and adaptative mathematical model to study the impact of folate deficiency, including folate transport and enzymes activities. 5-Methyltetrahydrofolate ...
Objective Synthetic folic acid is widely used, amongst others in the prevention of neural tube defects and reducing homocysteine, a risk factor for cardiovascular disease. Its effect on intracellular folate and the activity of essential cellular folate-converting enzymes is poorly understood. Methods Six lymphoblast cell lines were cultured for 15 days with medium containing either FA, 5-methyl...
Severe hyperhomocysteinemia due to cystathionine beta-synthase (CBS) deficiency is a strong risk factor for premature cardiovascular disease. Among untreated patients, approximately 50% have suffered a thromboembolic event by 30 years of age. We report on 3 sisters with severe hyperhomocysteinemia due to homozygosity for the CBS 833T-->C mutation. These patients, who displayed no other known th...
Recurrent pregnancy loss is usually defined as the loss of two or more consecutive pregnancies before 20 weeks of gestation, which occurs in approximately 5% of reproductive-aged women. It has been suggested that women with thrombophilia have an increased risk of pregnancy loss and other adverse pregnancy outcomes. Thrombophilia is an important predisposition to blood clot formation and is cons...
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