Apatinib, an antiangiogenic drug, has shown beneficial effects only in a fraction of advanced gastric cancer (GC) patients. Given the recent success immunotherapies, combination apatinib with immune checkpoint inhibitor may provide sustained and potent antitumor responses. Immunocompetent mice subcutaneous MFC tumors grown were given anti-PD-L1 antibody therapy. GC tissues from patients undergo...

Background: The characteristics of glioblastoma, such as drug resistance during treatment, short patient survival, and high recurrence rates, have made patients with glioblastoma more likely to benefit from oncolytic therapy. Methods: In this study, we investigated the safety sindbis virus by injecting intravenously intracranially in mice evaluated therapeutic effect carrying different combinat...

Abstract Sustained release of vaccine components is a potential method to boost efficacy compared with traditional bolus injection. Here, we show that biodegradable hyaluronic acid (HA)‐scaffold, termed HA cryogel, mediates sustained antigen and adjuvant in vivo leading durable immune response. Delivery from subcutaneously injected cryogels was assessed formulation which enhanced the response w...

Costimulation blockade induces prolonged rat islet and skin xenograft survival in C57BL/6 mice. Nonobese diabetic (NOD) mice, which are used to model human autoimmune diabetes, are resistant to costimulation blockade-induced allograft tolerance. We tested the hypothesis that NOD mice would also be resistant to costimulation blockade-induced rat xenograft tolerance. We report that rat islet xeno...

The survival time of germfree Swiss-Webster mice to whole-body X-irradia tion in the range of 500 to 35,000 R was compared to that of conventional Swiss Webster mice. The relationship between the survival time and X-ray dose administered to germfree and conventional mice shows three different straight line segments and cne curved segment, each with distinctive dose response characteristics on a...

Abstract The glioblastoma microenvironment is an immunosuppressive barrier to therapeutic innovation. We hypothesized intratumor convection enhanced delivery (CED) of gene therapy vectors could reprogram the immune and elucidate vulnerabilities. To test this, SB28 or GL261 allografts were implanted into immunocompetent mice treated with CED attenuated adeno-associated virus 9 (AAV9) encoding ex...

Introduction: As a physical treatment, electrochemical therapy (ECHT) has provided an effective and useful  approach  for  treating  localized  tumors.  The  chemical  changes  due  to  a  direct  electric  current  destroy  the  tumor. This study evaluates the effect of electrical dose and polarity on the efficacy of the treatment of a  colon tumor model.  Materials and Methods: In order to in...

Cachexia is the involuntary wasting of skeletal muscle and adipose tissue, affecting over 80% patients with pancreatic ductal adenocarcinoma (PDAC). Gemcitabine nab-paclitaxel (GemNP) combination are commonly given as first-line treatments for PDAC. Data from our lab showed GemNP reduced tumor growth prevented fat wasting. Dimethylaminoparthenolide (DMAPT), a small molecule inhibitor, prolonged...

Background: Infertility problem affects 20-30% of young couples. One of the known causes of spermatogenesis disorder is chemotherapy in patients with cancer which its side effect may last up to the end of the life. The aim of the present study is to investigate the effect of GnRH on viability of ovarian follicles defect produced by anticancer drug. Materials and Methods: In the present study ad...

Purpose: To study the effect of bioactive whey protein-supplemented paclitaxel on nutritional status and tumor growth in a mouse model subcutaneously transplanted triple negative breast cancer (TNBC).Methods: Eighty (80) mice were equally assigned to chemotherapy control groups. The chemotherapy-treated received chemotherapy, while group only. Differences body weight, glutathione (GSH) contents...