A new cooling scheme is proposed where the primary working fluid flowing through a micro-channel heat sink is pre-cooled to low temperature using an indirect refrigeration cooling system. Cooling performance was explored using HFE 7100 as working fluid and four different micro-channel sizes. High-speed video imaging was employed to help explain the complex interrelated influences of hydraulic d...

BACKGROUND Bioartificial liver support system (BALSS) based on culturing hepatocytes is an important research field for the treatment of acute liver failure. It is necessary to monitor the state of liver cell functions during the treatment of BALSS in order to guide clinical treatment. OBJECTIVE To design a micro-channel chip to achieve flash mixing for timely detection of liver cell status i...

This paper explores the subcooled nucleate boiling and critical heat flux (CHF) characteristics of a hybrid cooling module that combines the cooling attributes of micro-channel flow and jet impingement. A test module was constructed and tested using HFE-7100 as working fluid. Increasing the coolant’s flow rate and/or subcooling shifted both the onset of boiling (ONB) and CHF to higher heat flux...

The near-wall enrichment of platelets strongly influences thrombus formation in vivo and in vitro . This paper develops a multi-constituent continuum approach to study this phenomenon. A mixture theory model is used to describe the motion of plasma and red blood cells (RBCs) and the interactions between the two components. A transport model is developed to study the influence of the RBCs field ...

In the present research a numerical investigation has been made to evaluate the results of analytical approach in the analysis of micro channel heat sink (MCHS) which is increasingly used in the cooling of high heat dissipating electronic devices. In this regard the effects of geometrical and flow parameters affecting the absolute thermal resistance of MCHS have been analyzed. The effect of usi...

Cell entry into a micro-channel has potential applications in cell sorting and cancer diagnostics. In this paper, we numerically model breast cancer cell entry into a constricted micro-channel. Our results indicate that the cell velocity decreases during entry and increases after entry, an observation in agreement with experiments. We found that the cell entry time depend strongly on the cortic...

Due to the need for practical cooling technologies which could dissipate high heat fluxes, an experimental study of pressure drop and CHF in mini-channel (L) = 2.54 mm) and micro-channel (0 = 510 pm) heat sinks of 1 cm heated length was performed using R-l 13. Test conditions included inlet subcooling ranging from 10 to 32°C and a range of low flow rates up to a maximum of 95 ml min-‘. The test...

Flow development and pressure drop were investigated both experimentally and computationally for adiabatic single-phase water flow in a single 222 m wide, 694 m deep, and 12 cm long rectangular micro-channel at Reynolds numbers ranging from 196 to 2215. The velocity field was measured using a micro-particle image velocimetry system. A three-dimensional computational model was constructed which ...

Some studies on the fabrication of micro-needles, micro-pillers, and micro-channels using SU-8 negative photoresist for MEMS and bio-applications are reported. The SU-8 processing technology was standardized for the purpose. Micro-pillars were fabricated on SU-8 polymer by soft lithographic technique. Micro-needles were realized on SU-8 film utilizing lensing effect of the etched groove structu...