Retina is a network layer containing light-sensitive cells. Diseases that occur in this layer, which performs the eyesight, threaten our eye-sight directly. Diabetic Retinopathy is one of the main complications of diabetes mellitus and it is the most significant factor contributing to blindness in the later stages of the disease. Therefore, early diagnosis is of great importance to prevent the ...

In this study, 121 patients who showed diabetic or decreased glucose tolerance and were treated with diet alone for one to fifteen years were investigated as subclinical diabetes. Glucose tolerance in these patients was improved or remained unchanged during the clinical course. Aggravation in glucose tolerance was observed in only seven cases. However, abnormalities in glucose tolerance were st...

The retinal vasculature of postmortem normal human and diabetic eyes was studied using an immunohistochemical technique in conjunction with confocal laser scanning microscopy. The technique, which stained for von Willebrand factor, allowed both large areas of the retinal vasculature to be visualised and abnormalities to be studied in detail without disturbing the tissue architecture. Only one m...

Background. It is estimated that 347 million people suffer from diabetes mellitus (DM), and almost 5 million are blind due to diabetic retinopathy (DR). The progression of DR can be slowed down with early diagnosis and treatment. Therefore our aim was to develop a novel automated method for DR screening. Methods. 52 patients with diabetes mellitus were enrolled into the project. Of all patients...

Over the past few years diabetic retinopathy has proved to be a leading cause of blindness in adult population. WHO studies in 2002 showed that the diabetic retinopathy accounts for nearly 5% of the 37 million visually challenged people worldwide. The number of diabetic retinopathy patients around the globe is expected to increase from 127 million in 2010 to 191 million in 2030. An innovative a...

Several mechanisms are implicated in the pathogenesis of diabetic retinopathy. They include biochemical, hemodynamic, and hormonal factors, all of which have an important role in the development of diabetic retinopathy. These factors are not independent of each other, but rather they interact and together are responsible for the well-known lesions of vascular occlusion, microaneurysms, hemorrha...

Serum growth hormone levels were measured during insulin tolerance tests in 36 patients after yttrium-90 pituitary implantation for diabetic retinopathy. The response of the new blood vessels was more clearly related to loss of growth hormone function than was the improvement of retinal haemorrhages and microaneurysms. The overall response of the retinopathy was greatest when growth hormone fun...

ONLY 10 years ago laboratory research on the problem of diabetic retinopathy was confined to a few investigators working in isolated ophthalmological centres, but to-day it is attracting widespread attention from many different quarters and the literature is alive with new observations and new theories. It is therefore timely to consider to what extent the various pathological features of the d...

Five insulin dependent diabetic patients are reported on who had a few small retinal cotton-wool spots or 'soft exudates' either totally isolated or associated with fewer than 10 microaneurysms. These observations suggest that cotton-wool spots may be an early finding in diabetic retinopathy. Significant biological abnormalities in these patients were high levels of glycosylated haemoglobin and...

Purpose To investigate microvascular changes in the superficial capillary plexus (SCP) and deep capillary plexus (DCP) in eyes with resolved branch retinal vein occlusion (BRVO) and their association with best-corrected visual acuity (BCVA). Methods Eighty-five eyes (82 consecutive patients) with BRVO after resolution of the macular edema were retrospectively evaluated. All patients underwent...