This paper presents a simple fluid handling technique for microchip immunoassay. Necessary solutions were sequentially injected into a microchannel by air-evacuated poly(dimethylsiloxane), and were passively regulated by capillary force at the inlet opening. For heterogeneous immunoassay, microchips are potentially useful for reduction of sample consumption and assay time. However, most of the ...

The compatibility of polydimethylsiloxane (PDMS) channels with certain solvents is a well known problem of soft lithography techniques, in particular when it leads to the swelling of the PDMS blocks. However, little is known about the modification of microchannel geometries when they are subjected to swelling solvents. Here, we experimentally measure the deformations of the roof of PDMS microch...

The diffusion phenomena, dispersion and mixing processes of the sample solute (Basic Blue 3 dye and KMnO4 aqueous solutions) were directly observed in laminar flow in glass microchannels. Quasi steady-state UV-visible absorption spectrometry was carried out using CCD camera images of the colored sample dispersion and mixing processes, and the absorbance change (DeltaAbs) was discussed based on ...

In this work we report on a simple inertial microfluidic device that achieves continuous multi-particle separation using the principle of Dean-coupled inertial migration in spiral microchannels. The dominant inertial forces coupled with the Dean rotational force due to the curvilinear microchannel geometry cause particles to occupy a single equilibrium position near the inner microchannel wall....

A numerical model for the adsorption kinetics of proteins on the walls of a microchannel has been developed using the finite element method (FEM) to address the coupling with diffusion phenomena in the restricted microchannel volume. Time evolutions of the concentration of one species are given, both in solution and on the microchannel walls. The model illustrates the adsorption limitation some...

In this study, surface modification of iron (II, III) oxide Fe₃O₄ nanoparticles by oleic acid (OA) coating is investigated for the microablation of fat in a microchannel. The nanoparticles are synthesized by the co-precipitation method and then dispersed in organic solvent prior to mixing with the OA. The magnetization, agglomeration, and particle size distribution properties of the OA-coated F...

Microchannels are currently being used in many areas and have high potential for applications in many other areas. The application areas include Micro-Electro-Mechanical Systems (MEMS), microfuidics such as microchannel heat sinks for cooling micro-chips and laser diode arrays, LabOn-Chip devices for chemical and bio-medical analyses, biotechnology, telecommunications, metrology, computer techn...

Flow behaviour monitoring on the micro-scale is very important in many industrial and biochemical process. Electrical resistance tomography (ERT), as an alternative technique to visualize multi-phase flows, has high temporal resolution for monitoring fast transient processes. However, the complexity of microchannel fabrication end up with the difficulty of electrical data sampling and the nonli...

Two-phase flow instability in microchannel flow boiling exhibits pressure fluctuations with different frequencies and amplitudes. One possible way to suppress the dynamic instability is to introduce synthetic jet near the inlet of the channel. An important feature of synthetic jet is that it allows momentum transfer into the microchannel flow without net mass injection into it. The strength and...

We present a normally closed, remotely actuated, secure coded, electrostatically driven active microvalve using passive components. This is carried out by utilizing the complex signal processing capabilities of two identical 5 × 2-bit Barker sequence encoded acoustic wave correlators. An electrostatically driven microchannel, comprising two conducting diaphragms as the top and bottom walls, is ...