DOI: 10.1002/elps.202200295 The cover picture shows yellow and blue nanoparticles attracted to the electrodes of a microelectrode array designed for dielectrophoresis-based particle collection in high conducting media such as plasma. A protective hydrogel layer forms dome structure over when an electric field is applied. domes likely have insulative effect which intensifies gradient at electrod...

In the past, doctors usually treated disorders of the nervous system by substitution instead of correction, including wheelchairs for walking, braille for text, and sign language for speech. However, as our understanding of the nervous system increases, so does our ability to treat its disorders with neural prostheses that directly stimulate the nervous system. Cochlear implants are one example...

BACKGROUND Reducing cost and time is the major concern in clinical diagnostics, particularly in molecular diagnostics. Miniaturization technologies have been recognized as promising solutions to provide low-cost microchips for diagnostics. With the recent advancement in nanotechnologies, it is possible to further improve detection sensitivity and simplify sample preparation by incorporating nan...

The cochlear implant, a microelectrode array that directly stimulates the auditory nerve, has greatly benefited many individuals with profound deafness. Deaf patients without an intact auditory nerve may be helped by the next generation of auditory prostheses: surface or penetrating auditory brainstem implants that bypass the auditory nerve and directly stimulate auditory processing centers in ...

transcription and protein synthesis-dependent plasticity Microelectrode array recordings of cultured hippocampal networks reveal a simple model for including high-resolution figures, can be found at: Updated information and services publishes original articles on the function of the nervous system. It is published 12 times a year (monthly) Journal of Neurophysiology

Nitric oxide (NO), a biological mediator involved in vascular physiology, was sensed electrochemically using a microelectrode array. Angiogenin was shown to trigger nitric oxide synthase (NOS) activity in human umbilical vein endothelial cells and embryonic stem cell derived endothelial cells independently from its RNase activity.

We report a method for detecting microRNAs encapsulated in exosomes using a microelectrode array in semiconductor-based potentiometry after RT-PCR. The inherent miniaturization of the electrical biosensor meets requirements for massively parallel analysis of circulating microRNA as a noninvasive biomarker.