BACKGROUND The increased incidence of inflammatory diseases has necessitated the need to search for new topical dosage form of dexamethasone. OBJECTIVES The purpose of the present study was the preparation and evaluation of novel microemulsion as a topical delivery system for dexamethasone by mixing appropriate amount of surfactant including Tween 80 and Labrasol, cosurfactant such as capryol...

An orthogonal self-assembled system consists of different structures which coexist independently. Furthermore, the characteristic properties of the respective "base systems", i.e. of the systems which contain only one of the structures, are retained in the orthogonal self-assembled system. We have identified gelled bicontinuous microemulsions as orthogonal self-assembled systems and reported in...

A new method to produce cellulose nanofibrils (CNF) is proposed to reduce the energy demand during deconstruction of precursor fibers suspended in aqueous media. Microemulsions were formulated with aqueous solutions of urea or ethylenediamine and applied to disrupt interfibril hydrogen bonding. Compared to typical fibrillation of lignin-containing and lignin-free fibers, pretreatment with micro...

Tacrolimus and cyclosporine in the microemulsion formulation Neoral have demonstrated improvements in acute rejection rates after renal transplantation compared with conventional cyclosporine formulation, Sandimmune. To evaluate whether these drugs are also associated with improvements in chronic allograft failure (CAF) rates, we retrospectively analyzed 32,040 primary renal allograft recipient...

Treatment of Psoriasis Abstract Mycophenolate mofetil (MMF), the morpholinoethyl ester of mycophenolic acid is an immunosuppressive agent used to prevent organ rejection after kidney and heart transplant. The drug seem to be effective in dermal diseases mainly psoriasis. However, till date it can be only be administered using systemic route which is often associated with side effects such as na...

The microemulsion systems, both o/w and w/o, composed of isopropyl myristate, soybean lecithin (Epikuron 200), Polysorbate 80, Cremophor EL, n-butanol and triacetine, taken at various amounts and in various combinations, were tested in order to assess their physical-chemical properties. Some ingredients of the microemulsions were physiologically acceptable, except one formulation containing n-b...

We study the interplay between microphase assembly and macrophase separation in A/B/AB ternary polymer blends by examining the free energy of localized fluctuation structures (micelles or droplets), with emphasis on the thermodynamic relationship between swollen micelles (microemulsion) and the macrophase-separated state, using self-consistent field theory and an extended capillary model. Upon ...

We present an innovative methodology for the sustained delivery of hydrophobic drugs using composite hydrogels, prepared by embedding oil-in-water microemulsions in hydrophilic hydrogels. The hydrophobic nature of the microemulsion core enhances the solubilization of hydrophobic drugs, while the crosslinked matrix could be readily used as a solid controlled delivery vehicle. A microemulsion was...

This study aimed at designing mucoadhesive microemulsion gel to enhance the brain uptake of Ibuprofen through intranasal route. Ibuprofen loaded mucoadhesive microemulsion (MMEI) was developed by incorporating polycarbophil as mucoadhesive polymer into Capmul MCM based optimal microemulsion (MEI) and was subjected to characterization, stability, mucoadhesion and naso-ciliotoxicity study. Brain ...

In this study the effect of temperature, NaCl and oils (hydrocarbons: C(8)-C(16)) on the formation and solubilization capacity of the systems of oil/monoacylglycerols (MAG):ethoxylated fatty alcohols (CEO(20))/propylene glycol (PG)/water was investigated. The effects of the surfactant mixture on the phase behavior and the concentration of water or oil in the systems were studied at three temper...