نتایج جستجو برای: microfluidic biochips

تعداد نتایج: 18179  

2014
Dongmei Zhou Ben Shieh Alvin Louie Andrew Alek Tuen

Intracellular calcium ([Ca]i) regulates a diverse range of cellular functions and signaling pathways. This review article aims to highlight applications of microfluidic single-cell analysis in drug discovery including drug efficacy test and drug side-effect test, based on intracellular calcium measurement.

Journal: :Lab on a chip 2007
Yi-Shao Liu T M Walter Woo-Jin Chang Kwan-Seop Lim Liju Yang S W Lee A Aronson R Bashir

In this paper, we present a new impedance-based method to detect viable spores by electrically detecting their germination in real time within microfluidic biochips. We used Bacillus anthracis Sterne spores as the model organism. During germination, the spores release polar and ionic chemicals, such as dipicolinic acid (DPA), calcium ions, phosphate ions, and amino acids, which correspondingly ...

2011
Chia-Yu Lee Ting-Chou Chang Shau-Chun Wang Chih-Wei Chien Chung-Wei Cheng

We have successfully employed femtosecond laser to craft microstructures on polymeric substrate to imbed micro-mixiers. Since the laser pulse is ultra-short, the heat affected zone is not significant. Therefore the thermal melting damage is not as severe as that using continuous carbon dioxide laser. As a result, using femtosecond laser the fabrications of reproducible and defined micro-structu...

2014
XiuJun Li CH Li

Intracellular calcium ([Ca]i) regulates a diverse range of cellular functions and signaling pathways. This review article aims to highlight applications of microfluidic single-cell analysis in drug discovery including drug efficacy test and drug side-effect test, based on intracellular calcium measurement.

Journal: :Lab on a chip 2006
William H Grover Robin H C Ivester Erik C Jensen Richard A Mathies

Novel latching microfluidic valve structures are developed, characterized, and controlled independently using an on-chip pneumatic demultiplexer. These structures are based on pneumatic monolithic membrane valves and depend upon their normally-closed nature. Latching valves consisting of both three- and four-valve circuits are demonstrated. Vacuum or pressure pulses as short as 120 ms are adequ...

2010
Sandro Carrara

Further advances in molecular medicine and cell biology also require new electrochemical systems to detect disease biomarkers and therapeutic compounds. Microelectronic technology offers powerful circuits and systems to develop innovative and miniaturized biochips for sensing at the molecular level. However, microelectronic biochips proposed in the literature often do not show the right specifi...

Journal: :Journal of Life Support Engineering 2007

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